K
Karen Legler
Researcher at University of Marburg
Publications - 6
Citations - 298
Karen Legler is an academic researcher from University of Marburg. The author has contributed to research in topics: Leptin & Insulin resistance. The author has an hindex of 6, co-authored 6 publications receiving 264 citations. Previous affiliations of Karen Legler include University of Otago.
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Journal ArticleDOI
Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance
Jonas Benzler,Goutham K. Ganjam,Dominik Pretz,Rebecca Oelkrug,Christiane E. Koch,Karen Legler,Sigrid Stöhr,Carsten Culmsee,Lynda M. Williams,Alexander Tups,Alexander Tups +10 more
TL;DR: A specific role of central proinflammatory IKKβ/NF-κB signaling in the development and potential treatment of DIO-induced comorbidities is reinforced.
Central inhibition of IKKβ/NFκB signalling attenuates high fat dietinduced obesity and glucose intolerance
Jonas Benzler,Goutham K. Ganjam,Dominik Pretz,Rebecca Oelkrug,Karen Legler,Sigrid Stöhr,Carsten Culmsee,Lynda M. Williams,Alexander Tups,Aberdeen Ab +9 more
TL;DR: In this paper, the authors investigated whether nutritive and genetic inhibition of the central IKKβ/NF-κB pathway in DIO- and leptin-deficient mice improves metabolic impairments.
Journal ArticleDOI
That’s hot: golden spiny mice display torpor even at high ambient temperatures
TL;DR: Investigation of golden spiny mice in the Judean desert shows that the occurrence of daily torpor is not necessarily linked to cold exposure and the development of a pronounced hypothermia, but may even occur as depression of metabolic rate in a hot environment.
Journal ArticleDOI
Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice.
Jonas Benzler,Goutham K. Ganjam,Karen Legler,Sigrid Stöhr,Manon Krüger,Juliane Steger,Alexander Tups +6 more
TL;DR: The data suggest that the acute inhibition of central JNK improves impaired glucose homeostasis and is associated with sensitisation of hypothalamic insulin signalling.
Journal ArticleDOI
Central adiponectin acutely improves glucose tolerance in male mice
Christiane E. Koch,Chrishanthi Lowe,Karen Legler,Jonas Benzler,Alisa Boucsein,Gregor Böttiger,David R. Grattan,Lynda M. Williams,Alexander Tups +8 more
TL;DR: In mice on a HF diet and in leptin-deficient mice acute ICV adiponectin improved glucose tolerance 60 minutes after injection, whereas normoglycemia in control mice was unaffected.