Kari R. Fischer

TL;DR: The potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment is suggested, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models.

TL;DR: An in vivo approach to track the fate of tumor cells based on a novel EMT-driven fluorescent color switching breast cancer mouse model and intravital two-photon laser scanning microscopy provides a novel opportunity for visualizing tumor EMT at the single-cell level and may reveal the intricacies underlying tumor dynamics and treatment responses.

TL;DR: Analysis of homogeneousStromal populations isolated directly from fresh clinical specimens can detect important stromal genes of therapeutic value and enhanced tumorigenic properties of lung cancer cells indicative of their potential as targets for therapy are demonstrated.

TL;DR: It is shown that the absence of Fto protein results in leanness and that Fto deficiency affects energy homeostasis and the experiments performed in mice conflict with results in humans carrying the FTO risk allele presenting hyperphagia and increased caloric intake.

TL;DR: A novel and unique EMT lineage tracing system is established in spontaneous breast to lung metastasis models and suggests the potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, in the treatment of breast cancer patients.