Hyejin Choi

TL;DR: The potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment is suggested, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models.

TL;DR: It is suggested that selectively targeting tumor-elicited myeloid cells or versican represents a potential therapeutic strategy for combating metastatic disease.

TL;DR: In this paper, the authors identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer.

TL;DR: This study used an orthotopic model of Kras-driven NSCLC to systematically dissect the contribution of specific hematopoietic stromal cells in lung cancer and developed a computational model for crosstalk signaling discovery based on ligand-receptor interactions and downstream signaling networks and identified known and novel tumor-stroma paracrine and tumor autocrine crosStalk-signaling pathways inNSCLC.

TL;DR: A 5-amino acid peptide with Tsp-1–inducing activity was identified as a therapeutic agent against metastatic cancer and developed as a pharmacologic inducer of TSp-1 in Gr1(+) bone marrow cells, which dramatically suppressed metastasis.