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Nasser K. Altorki
Researcher at NewYork–Presbyterian Hospital
Publications - 421
Citations - 31332
Nasser K. Altorki is an academic researcher from NewYork–Presbyterian Hospital. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 83, co-authored 382 publications receiving 27089 citations. Previous affiliations of Nasser K. Altorki include University of Chicago & Cornell University.
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Journal ArticleDOI
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
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Early Lung Cancer Action Project: overall design and findings from baseline screening
Claudia I. Henschke,Dorothy I. McCauley,David F. Yankelevitz,David P. Naidich,Georgeann McGuinness,Olli S. Miettinen,Daniel M. Libby,Mark W. Pasmantier,June Koizumi,Nasser K. Altorki,James P. Smith +10 more
TL;DR: Low-dose CT can greatly improve the likelihood of detection of small non-calcified nodules, and thus of lung cancer at an earlier and potentially more curable stage, although false-positive CT results are common.
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer,Anna Durrans,Sharrell Lee,Jianting Sheng,Fuhai Li,Stephen T. C. Wong,Hyejin Choi,Tina El Rayes,Seongho Ryu,Seongho Ryu,Juliane S. Troeger,Robert F. Schwabe,Linda T. Vahdat,Nasser K. Altorki,Vivek Mittal,Dingcheng Gao +15 more
TL;DR: The potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment is suggested, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models.
Journal ArticleDOI
Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: A propensity-matched analysis from the STS database
Subroto Paul,Nasser K. Altorki,Shubin Sheng,Paul C. Lee,David H. Harpole,Mark W. Onaitis,Brendon M. Stiles,Jeffrey L. Port,Thomas A. D'Amico +8 more
TL;DR: Video-assisted thoracoscopic lobectomy is associated with a lower incidence of complications compared with lobectomy via thoracotomy, and may be the preferred strategy for appropriately selected patients with lung cancer.
Journal ArticleDOI
TOX is a critical regulator of tumour-specific T cell differentiation
Andrew Scott,Andrew Scott,Friederike Dündar,Paul Zumbo,Smita S. Chandran,Christopher A. Klebanoff,Mojdeh Shakiba,Mojdeh Shakiba,Prerak Trivedi,Laura Menocal,Laura Menocal,Heather Appleby,Steven Camara,Dmitriy Zamarin,Tyler Walther,Alexandra Snyder,Matthew R. Femia,Elizabeth A. Comen,Elizabeth A. Comen,Hannah Y Wen,Matthew D. Hellmann,Matthew D. Hellmann,Niroshana Anandasabapathy,Y. Liu,Nasser K. Altorki,Peter Lauer,Olivier Levy,Michael S. Glickman,Michael S. Glickman,Jonathan Kaye,Doron Betel,Mary Philip,Mary Philip,Andrea Schietinger,Andrea Schietinger +34 more
TL;DR: It is hypothesized that the TOX-induced exhaustion program serves to prevent the overstimulation of T cells and activation-induced cell death in settings of chronic antigen stimulation such as cancer.