K
Karin Thevissen
Researcher at Katholieke Universiteit Leuven
Publications - 173
Citations - 13665
Karin Thevissen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Candida albicans & Plant defensin. The author has an hindex of 49, co-authored 168 publications receiving 11610 citations. Previous affiliations of Karin Thevissen include Catholic University of Leuven.
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Journal ArticleDOI
Synthetic peptides derived from the beta2-beta3 loop of Raphanus sativus antifungal protein 2 that mimic the active site.
W.M.M. Schaaper,Geertruida Afina Posthuma,H.H. Plasman,Lolke Sijtsma,Franky Fant,Frans Borremans,Karin Thevissen,Willem F. Broekaert,R.H. Meloen,A. van Amerongen +9 more
TL;DR: This study synthesized linear 19-mer peptides, spanning the entire beta2-beta3 loop, that were found to be almost as potent as Rs-AFP2 and cause increased Ca2+ influx in pregerminated fungal hyphae.
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Miconazole induces changes in actin cytoskeleton prior to reactive oxygen species induction in yeast.
Karin Thevissen,Kathryn R. Ayscough,An M. Aerts,Wei Du,Katrijn De Brucker,Els M.K. Meert,Jannie Ausma,Marcel Borgers,Bruno P. A. Cammue,Isabelle E.J.A. François +9 more
TL;DR: It is demonstrated that miconazole induces changes in the actin cytoskeleton, indicative of increased filament stability, prior to ROS induction, which provides novel mechanistic insights in the mode of action of a ROS-inducing azole.
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The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms
Anna Bink,Soňa Kucharíková,Bram Neirinck,Jef Vleugels,Patrick Van Dijck,Bruno P. A. Cammue,Karin Thevissen +6 more
TL;DR: It is indicated that diclofenac could be useful in combination therapy with caspofungin to treat C. albicans biofilm-associated infections.
Journal ArticleDOI
Ceramide involvement in apoptosis and apoptotic diseases.
Karin Thevissen,Isabelle E.J.A. François,Joris Winderickx,Christophe Pannecouque,Bruno P. A. Cammue +4 more
TL;DR: The present review summarizes the molecular basis and regulation of the apoptotic machinery, the molecular role of ceramides in the induction or execution of apoptotic pathways, and evidence linking ceramide generation to various apoptotic diseases.
Journal ArticleDOI
The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.
Erwin Swinnen,Tobias Wilms,Jolanta Idkowiak-Baldys,Bart Smets,Pepijn De Snijder,Sabina Accardo,Ruben Ghillebert,Karin Thevissen,Bruno P. A. Cammue,Dirk De Vos,Jacek Bielawski,Yusuf A. Hannun,Joris Winderickx +12 more
TL;DR: The budding yeast protein kinase Sch9 is not only an effector, but also a regulator of sphingolipid metabolism, which provides a crucial link between nutrient and sphingalipid signaling.