K
Karin Wuertz
Researcher at University of Zurich
Publications - 29
Citations - 2170
Karin Wuertz is an academic researcher from University of Zurich. The author has contributed to research in topics: Intervertebral disc & Proinflammatory cytokine. The author has an hindex of 23, co-authored 29 publications receiving 1921 citations. Previous affiliations of Karin Wuertz include ETH Zurich & University of Vermont.
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Journal ArticleDOI
Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-κB and MAP kinases.
TL;DR: The current state of knowledge concerning the inflammatory and catabolic molecular pathways of intervertebral disc disease (IDD) are summarized, with a detailed description of NF-kB and MAP kinase-mediated signal transduction in disc cells, and the emerging novel molecular treatment modalities for IDD are discussed.
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Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration
Beatrice E. Bachmeier,Andreas G. Nerlich,Norbert Mittermaier,Christoph Weiler,Christianto Lumenta,Karin Wuertz,Norbert Boos +6 more
TL;DR: Data on the gene and protein level is provided, which highlights the key role of MMP-3 in the degenerative cascade leading to symptomatic disc degeneration and herniation and Control of the proteolytic activity of M MP-3 may, therefore, come into the focus when aiming to develop new treatment options for earlyDisc degeneration.
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Inflammatory mediators in intervertebral disk degeneration and discogenic pain.
TL;DR: This review provides information on the most relevant inflammatory mediators during different types of disk diseases and explains how these factors can induce disk degeneration and the development of discogenic and sciatic/radiculopathic pain.
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In Vivo Remodeling of Intervertebral Discs in Response to Short- and Long-Term Dynamic Compression
Karin Wuertz,Karolyn E. Godburn,Jeffrey J. MacLean,Ana Barbir,Justin Stinnett Donnelly,Peter J. Roughley,Mauro Alini,James C. Iatridis +7 more
TL;DR: It is concluded that dynamic compression is consistent with a notion of “healthy” loading that is able to maintain or promote matrix biosynthesis without substantially disrupting disc structural integrity.
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Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc.
TL;DR: IVD repair using MSCs requires increased knowledge of MSC response to the chemical microenvironment, and pH may be the major limitation for MSC-based IVD repair.