K
Karin Wuertz
Researcher at University of Zurich
Publications - 29
Citations - 2170
Karin Wuertz is an academic researcher from University of Zurich. The author has contributed to research in topics: Intervertebral disc & Proinflammatory cytokine. The author has an hindex of 23, co-authored 29 publications receiving 1921 citations. Previous affiliations of Karin Wuertz include ETH Zurich & University of Vermont.
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Journal ArticleDOI
Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells.
Karin Wuertz,Jill P. G. Urban,J. Klasen,Anita Ignatius,Hans-Joachim Wilke,Lutz Claes,Cornelia Neidlinger-Wilke +6 more
TL;DR: It is shown that the osmotic environment does not only have an appreciable effect on gene expression but also affects responses to mechanical stimuli, which suggests that the Osmotic conditions cannot be ignored when examining physiological and pathological behavior of IVD cells.
Journal ArticleDOI
Age-Related Variation in Cell Density of Human Lumbar Intervertebral Disc
TL;DR: This study provides data concerning the total number of cells in the various regions of the intervertebral disc for different age groups and found a significant correlation of cell density and histologic degeneration score between 0 and 1, but not for scores >1.
Journal ArticleDOI
Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc
Christoph Weiler,Andreas G. Nerlich,Rainer Schaaf,Beatrice E. Bachmeier,Karin Wuertz,Norbert Boos +5 more
TL;DR: It is indicated that cells with a (immunohistochemically) notochord-like phenotype are present in a considerable fraction of adult lumbar intervertebral discs of all ages and variable degree of disc degeneration.
Journal ArticleDOI
MSC response to pH levels found in degenerating intervertebral discs.
TL;DR: Acidity caused an inhibition of aggrecan, collagen-1, and TIMP-3 expression, as well as a decrease in proliferation and viability and was associated with a change in cell morphology, and ageing had generally minor effects but young MSCs maintained greater mRNA expression levels.
Journal ArticleDOI
Regenerative therapies for equine degenerative joint disease: a preliminary study.
Sarah Broeckx,Marieke Zimmerman,Sara Crocetti,Marc Suls,Tom Mariën,Stephen J. Ferguson,Koen Chiers,Luc Duchateau,Alfredo Franco-Obregón,Karin Wuertz,Jan H. Spaas +10 more
TL;DR: In vivo application of (induced) MSCs together with PRP in horses suffering from DJD in the fetlock joint resulted in a significant clinical improvement until 12 months after treatment.