Showing papers in "Journal of Orthopaedic Research in 2007"

TL;DR: Using recombinant adenoviruses expressing 14 BMPs, it is demonstrated that, besides BMP2 and BMP7, BMP6 and B MP9 exhibit the highest osteogenic activity both in vitro and in vivo, and that several B MPs may exert synergistic effect on osteogenic differentiation.

TL;DR: In vivo data collected from a single subject with an instrumented knee implant support the hypothesis that the knee adduction torque is highly correlated with medial compartment contact force and medial to total force ratio during gait.

TL;DR: The findings of this study support in vivo investigation of PRP as an autogenous, patient‐side treatment for tendonitis as well as other blood products tested.

TL;DR: Both the modified radiographic anteversion measurements and the cross‐over‐sign demonstrated substantial inter‐ and intraobserver reliability.

TL;DR: Current trends in nanobiotechnology foreshadow a bright future through the use of nanobiomaterials in the orthopedic domain through the uses of nanocomposites and nanostructured materials.

TL;DR: In conclusion, irrespective of age, gender, and source of isolation, cells from all donors showed osteogenic potential, and in vitro studies suggest a correlation between in vitro ALP expression and in vivo bone formation.

TL;DR: Mesenchymal stem cell grafts improved the early healing response, but did not significantly enhance the long‐term histologic appearance or biochemical composition of full‐thickness cartilage lesions.

TL;DR: It is concluded that use of a stabilized provisional scaffold, such as a collagen–PRP hydrogel, to supplement primary repair of the ACL can result in improved biomechanical properties at an early time point.

TL;DR: Results indicate that MPO and Cl‐peptides may serve as diagnostic markers for the detection of early OA.

TL;DR: This study supports the hypothesis that premature scaffold failure may play a key role in the normally expected failure of the ACL to heal after injury and shows that the use of a collagen‐PRP scaffold can ameliorate histologic differences noted between healing extra‐articular ligamentous wounds and nonhealing intra‐artic ligamentOUS wounds.

TL;DR: A novel modular composite implant design was used to achieve reproducible stable fixation, provide a window for longitudinal in vivo micro‐CT monitoring of 3D bone ingrowth, and allow torsional biomechanical testing of functional integration.

TL;DR: HipMotion is a useful tool for further assessment of impinging hips and for appropriate planning of the necessary amount of surgical intervention, which represents the basis for future computer‐assisted treatment of FAI with less invasive surgical approaches, such as hip arthroscopy.

TL;DR: A new paradigm for AF tissue engineering is proposed that focuses on the reconstitution of anatomic fiber architecture and uses constitutive modeling to evaluate construct function, suggesting that engineered constructs replicate the physiologic behavior of the single AF lamella.

TL;DR: Improved proprioceptive acuity following intervention with either exercise protocol may occur through an improved quality of cervical afferent input or by addressing input through direct training of relocation sense.

TL;DR: In vivo medial and lateral contact forces experienced by a well‐aligned knee implant for a variety of activities are reported by a single knee replacement patient performing treadmill gait, step up/down, lunge, and kneel activities.

TL;DR: The present study provides the first evidence that standardized particulate bone constructs can be used to repair large bone defects and that their osteogenic ability approaches that of bone autograft, the bone repair benchmark.

TL;DR: The variable combination of muscle adaptations that produce joint stiffness, and the ability of both the ankle and the hip to compensate for lower knee control indicate the non‐coper neuromuscular system may be more malleable than previously believed.

TL;DR: The mathematical relationships elucidated in the current study support previous clinical and basic science research examining noncontact ACL injuries and provides important evidence for clinicians who are examining the risk factors for these injuries and developing/validating training programs to reduce the incidence of injury.

TL;DR: The induction of a closed intraarticular fracture of the mouse tibial plateau generated a reproducible and clinically relevant joint injury that progressed to osteoarthritis‐like changes by histologic and microCT evaluations.

TL;DR: The data reveal that an ischemic insult in the hind limb prior to fracture leads to a delayed union or a nonunion, but does not favor formation of cartilage over bone.

TL;DR: The results suggest that tiny acceleratory motions — independent of direct loading of the matrix — can influence bone formation and bone morphology, and may ultimately facilitate the stimulation of skeletal regions that are prone to osteoporosis even in patients that are suffering from confinement to wheelchairs, bed rest, or space travel.

TL;DR: A subject‐specific laterally wedged orthotic device was able to reduce the peak knee adduction moment during early stance, which is thought to be associated with the progression of knee osteoarthritis.

TL;DR: It is demonstrated that a stable, bactericidal Ti surface is effectively engineered, which holds great promise in terms of mitigating or preventing periprosthetic infection.

TL;DR: Sustained delivery of growth factors may be achieved using a novel fibrin‐based delivery system that increased cell proliferation and matrix remodeling and thus may accelerate flexor tendon healing.

TL;DR: The study does not have evidence of an increased rate of primary malignancies nor could it detect renal failure in the study group, and serum metal levels did not differ from short‐ and intermediate term follow‐up values.

TL;DR: The results of this study suggest that by expressing more cartilage genes, the tendon is converting toward a fibrocartilage phenotype as a result of the repetitive loading and repeated compression of the tendon as it passes through the acromial arch.

TL;DR: Single‐plane X‐ray imaging with model‐based shape matching provides kinematic measurements with sufficient accuracy to assess knee motions using either MRI– or CT–derived bone models, however, extra care should be taken when using MRI– derived bone models because model inaccuracies will affect the quality of the shape matching results.

TL;DR: The results of this study support the null hypothesis suggesting that the patellar tendon is similar to other tendons and demonstrate that tendons have different characteristics to ligaments.

TL;DR: It is shown that the osmotic environment does not only have an appreciable effect on gene expression but also affects responses to mechanical stimuli, which suggests that the Osmotic conditions cannot be ignored when examining physiological and pathological behavior of IVD cells.

TL;DR: Implanted autologous chondrocytes could survive and could yield hyaline‐like cartilage in vivo in the biphasic biomaterial construct, and pre‐seeding of osteogenic cells did not appear to be necessary to regenerate subchondral bone.