K
Karina Peregrina
Researcher at Albert Einstein College of Medicine
Publications - 8
Citations - 108
Karina Peregrina is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Stem cell & Wnt signaling pathway. The author has an hindex of 3, co-authored 5 publications receiving 67 citations.
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Journal ArticleDOI
Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions
Karina Peregrina,Michele Houston,Cecilia Daroqui,Elena Dhima,Rani S. Sellers,Leonard H. Augenlicht +5 more
TL;DR: The contribution of Lgr5+ cells to intestinal homeostasis and tumor formation in humans may be significantly more limited, and variable in the population, then suggested by published rodent studies.
Journal ArticleDOI
The nutritional environment determines which and how intestinal stem cells contribute to homeostasis and tumorigenesis.
Wenge Li,Samuel E. Zimmerman,Karina Peregrina,Michele Houston,Joshua Mayoral,Jinghang Zhang,Shahina Maqbool,Zhengdong D. Zhang,Ying Cai,Kenny Ye,Leonard H. Augenlicht +10 more
TL;DR: The key role of the nutrient environment is established in defining the contribution of two different stem cell populations to both mucosal homeostasis and tumorigenesis, which raises important questions regarding impact of variable human diets on which and how stemcell populations function in the human mucosa and give rise to tumors.
Journal ArticleDOI
Vitamin D and the nutritional environment in functions of intestinal stem cells: Implications for tumorigenesis and prevention.
TL;DR: A key role of the nutrient environment, and vitamin D signaling, is established in defining contribution of at least two different stem cell populations to mucosal homeostasis and tumorigenesis in mice fed a purified rodent western-style diet.
Journal ArticleDOI
Transition state analogue of MTAP extends lifespan of APC Min/+ mice
Ross S. Firestone,Mu Feng,Indranil Basu,Karina Peregrina,Leonard H. Augenlicht,Vern L. Schramm +5 more
TL;DR: In this paper, the authors investigated the efficacy of MTDIA as an anti-cancer therapeutic for intestinal adenomas in immunocompetent APCMin/+ mice, a murine model of human Familial Adenomatous Polyposis.
Journal ArticleDOI
Bacterial hydrogen sulfide drives cryptic redox chemistry in gut microbial communities
Sarah J. Wolfson,Reese Hitchings,Karina Peregrina,Ziv Cohen,Saad Khan,T. Yilmaz,Marcel Malena,Edgar D. Goluch,Leonard H. Augenlicht,Libusha Kelly +9 more
TL;DR: In this paper , the authors show that microbially generated hydrogen sulfide (H2S) drives the abiotic reduction of azo (R-N = N-R') xenobiotics, which are commonly found in Western food dyes and drugs.