L
Libusha Kelly
Researcher at Albert Einstein College of Medicine
Publications - 66
Citations - 4336
Libusha Kelly is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Microbiome & Genome. The author has an hindex of 26, co-authored 58 publications receiving 3700 citations. Previous affiliations of Libusha Kelly include California Institute for Quantitative Biosciences & Yeshiva University.
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Journal ArticleDOI
MODBASE, a database of annotated comparative protein structure models, and associated resources
Ursula Pieper,Narayanan Eswar,Ben Webb,David Eramian,David Eramian,Libusha Kelly,Libusha Kelly,David T. Barkan,David T. Barkan,Hannah Carter,Parminder Mankoo,Rachel Karchin,Marc A. Marti-Renom,Fred P. Davis,Andrej Sali +14 more
TL;DR: A PSI:Biology initiative to maximize the structural coverage of the human alpha-helical transmembrane proteome and a determination of structural determinants of human immunodeficiency virus-1 protease specificity are highlighted.
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Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism
Luke R. Thompson,Qinglu Zeng,Libusha Kelly,Katherine H. Huang,Alex U. Singer,JoAnne Stubbe,Sallie W. Chisholm +6 more
TL;DR: It is proposed that phage-augmented NADPH production fuels deoxynucleotide biosynthesis for phage replication, and that the selection pressures molding phage genomes involve fitness advantages conferred through mobilization of host energy stores.
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Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments
Matthew B. Sullivan,Matthew B. Sullivan,Katherine H. Huang,Julio C. Ignacio-Espinoza,Aaron M. Berlin,Libusha Kelly,Peter Weigele,Peter Weigele,Alicia S. DeFrancesco,Suzanne E. Kern,Luke R. Thompson,Sarah Young,Chandri Yandava,Ross Fu,Bryan Krastins,Michael R. Chase,David A. Sarracino,Marcia S. Osburne,Matthew R. Henn,Sallie W. Chisholm +19 more
TL;DR: Comparisons of both diverse and closely related, co-isolated genomes provide a locus-to-locus variability metric that will prove valuable for interpreting metagenomic data sets.
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Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria.
Bo Li,Daniel Sher,Libusha Kelly,Yanxiang Shi,Katherine H. Huang,Patrick J. Knerr,Ike Joewono,Doug Rusch,Sallie W. Chisholm,Wilfred A. van der Donk +9 more
TL;DR: It is shown that a strain of the single-celled, planktonic marine cyanobacterium Prochlorococcus—which conducts a sizable fraction of photosynthesis in the oceans—produces many cyclic, lanthionine-containing peptides (lantipeptides).
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LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources
Rachel Karchin,Mark Diekhans,Libusha Kelly,Daryl J. Thomas,Ursula Pieper,Narayanan Eswar,David Haussler,Andrej Sali +7 more
TL;DR: LS-SNP comprehensively maps ns SNPs onto protein sequences, functional pathways and comparative protein structure models, and predicts positions where nsSNPs destabilize proteins, interfere with the formation of domain-domain interfaces, have an effect on protein-ligand binding or severely impact human health.