K
Karine Boulay
Researcher at Université de Montréal
Publications - 15
Citations - 901
Karine Boulay is an academic researcher from Université de Montréal. The author has contributed to research in topics: Senescence & RNA. The author has an hindex of 9, co-authored 13 publications receiving 574 citations. Previous affiliations of Karine Boulay include Jewish General Hospital & German Cancer Research Center.
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Journal ArticleDOI
mTOR as a central regulator of lifespan and aging.
David Papadopoli,Karine Boulay,Lawrence Kazak,Michael Pollak,Frédérick A. Mallette,Ivan Topisirovic,Laura Hulea +6 more
TL;DR: This review highlights the emerging insights that link mTOR to various processes related to aging, such as nutrient sensing, maintenance of proteostasis, autophagy, mitochondrial dysfunction, cellular senescence, and decline in stem cell function.
Journal ArticleDOI
Interaction of Staufen1 with the 5′ end of mRNA facilitates translation of these RNAs
Samuel Dugré-Brisson,George Elvira,Karine Boulay,Laurent Chatel-Chaix,Andrew J. Mouland,Luc DesGroseillers +5 more
TL;DR: The results support a model in which the expression of Staufen1 and its interaction with the 5′ end of RNA and ribosomes facilitate translation initiation, and suggest that St Saufen1-binding to the 5″ end is required for enhanced translation.
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A pan-cancer analysis of synonymous mutations.
Yogita Sharma,Milad Miladi,Sandeep Dukare,Karine Boulay,Maïwen Caudron-Herger,Matthias Groß,Rolf Backofen,Sven Diederichs +7 more
TL;DR: A catalogue of synonymous mutations in cancer and characterise their properties is presented, indicating that single point mutations can have a relevant impact on expression as well as on mRNA secondary structure.
Journal ArticleDOI
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.
Francois Binet,Gael Cagnone,Sergio Crespo-Garcia,Masayuki Hata,Mathieu Neault,Agnieszka Dejda,Ariel M. Wilson,Manuel Buscarlet,Gaelle Mawambo,Joel P. Howard,Roberto Diaz-Marin,Célia Parinot,Vera Guber,Frédérique Pilon,Rachel Juneau,Rémi Laflamme,Christina Sawchyn,Karine Boulay,Severine Leclerc,Afnan Abu-Thuraia,Jean-François Côté,Gregor Andelfinger,Flavio A. Rezende,Florian Sennlaub,Jean-Sébastien Joyal,Frédérick A. Mallette,Przemyslaw Sapieha,Przemyslaw Sapieha +27 more
TL;DR: Understanding how diseased blood vessels remodel and yield functional networks has the potential to lead to strategies that enhance vascular normalization and helps to explain why retinas in certain patients have the propensity to repair themselves more readily than others.
Journal ArticleDOI
Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling
Laurence M. Gagné,Karine Boulay,Karine Boulay,Ivan Topisirovic,Ivan Topisirovic,Marc-Étienne Huot,Frédérick A. Mallette +6 more
TL;DR: Recent advances on the elucidation of oncogenic functions of IDH1/2 mutations, and of the associated oncometabolite R-2HG, which link altered metabolism of cancer cells to epigenetics, RNA methylation, cellular signaling, hypoxic response, and DNA repair are reviewed.