Karl P. Fischer

TL;DR: These chimeric mice represent the first murine model suitable for studying the human hepatitis C virus in vivo and are considered to be a first-of-its-kind model.

TL;DR: It is likely that the methionine‐to‐ isoleucine mutation in the YMDD motif of the HBV polymerase contributes significantly to the lamivudine‐resistance of HBV isolated from this patient.

TL;DR: Results demonstrated that codelivery of HBcAg and MPLA in PLGA nanoparticles promotedHBcAg-specific Th1 immune responses with IFN-gamma production, suggesting that appropriate design of the vaccine formulation and careful planning of the immunization schedule are important in the successful development of effective HBV therapeutic vaccines.

TL;DR: It is shown that lamivudine can effectively inhibit hepatitis B virus in cirrhotic patients pretransplant and posttransplant, and viral resistance is likely to be a significant problem.

TL;DR: In this article, six different zinc finger proteins (ZFPs) were designed to bind DNA sequences in the DHBV enhancer region, and the binding kinetics were assessed by using electrophoretic mobility shift assays and surface plasmon resonance.