W
Winnie Wong
Researcher at University of Alberta
Publications - 25
Citations - 1401
Winnie Wong is an academic researcher from University of Alberta. The author has contributed to research in topics: Liver transplantation & Immunosuppression. The author has an hindex of 16, co-authored 24 publications receiving 1343 citations.
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Journal ArticleDOI
Sirolimus‐based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma
Norman M. Kneteman,Jose Oberholzer,Mohammed Al Saghier,Glenda Meeberg,Maurice Blitz,Mang Ma,Winnie Wong,Klaus S. Gutfreund,Andrew Mason,L D Jewell,A. M. James Shapiro,Vincent G. Bain,David L. Bigam +12 more
TL;DR: The Milan criteria for liver transplantation in the presence of HCC can be carefully extended without compromising outcomes and this sirolimus based immunosuppression protocol appears to have beneficial effects on tumor recurrence and survival with an acceptable rate of rejection and toxicity.
Journal ArticleDOI
Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery
Carrie S.W. Chong,Min Cao,Winnie Wong,Karl P. Fischer,William R. Addison,Glen S. Kwon,Glen S. Kwon,D. Lorne Tyrrell,John Samuel +8 more
TL;DR: Results demonstrated that codelivery of HBcAg and MPLA in PLGA nanoparticles promotedHBcAg-specific Th1 immune responses with IFN-gamma production, suggesting that appropriate design of the vaccine formulation and careful planning of the immunization schedule are important in the successful development of effective HBV therapeutic vaccines.
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De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects.
Christian Toso,Glenda Meeberg,David L. Bigam,Jose Oberholzer,A M. J. Shapiro,Klaus S. Gutfreund,Mang Ma,Andrew Mason,Winnie Wong,Vincent G. Bain,Norman M. Kneteman +10 more
TL;DR: De novo sirolimus-based immunosuppression is associated with satisfactory outcomes after transplantation, even in selected patients beyond Milan criteria, and the protocol has proven safe, with an acceptable side-effect profile.
Journal ArticleDOI
Management of chronic hepatitis C: Consensus guidelines
Morris Sherman,Stephen D. Shafran,Kelly W. Burak,Karen Doucette,Winnie Wong,Nigel Girgrah,Eric M. Yoshida,Eberhard L. Renner,Philip Wong,Marc Deschênes +9 more
TL;DR: The present document reviews the epidemiology of hepatitis C in Canada, treatment of acute hepatitis C and new algorithms in chronic hepatitis C, including retreatment of previous treatment failures and the use of hematopoietic growth factors to help manage patients on therapy.
Journal ArticleDOI
Half-Life of the Duck Hepatitis B Virus Covalently Closed Circular DNA Pool In Vivo following Inhibition of Viral Replication
William R. Addison,Kathie-Anne Walters,Winnie Wong,John S. Wilson,Danuta Madej,Lawrence D. Jewell,D. Lorne Tyrrell +6 more
TL;DR: Liver sections stained for the cell division marker PCNA showed that animals in which cccDNA loss was continuous had significantly greater numbers of PCNA-positive nuclei than did those animals inWhich ccc DNA levels had plateaued, suggesting the selection of drug-resistant virus mutants is an unlikely explanation for this unexpected stabilization of cCCDNA levels.