K
Karthik Viswanathan
Researcher at Massachusetts Institute of Technology
Publications - 38
Citations - 3029
Karthik Viswanathan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Hemagglutinin (influenza) & Glycan. The author has an hindex of 22, co-authored 38 publications receiving 2823 citations. Previous affiliations of Karthik Viswanathan include Charles Stark Draper Laboratory & University of Massachusetts Medical School.
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Journal ArticleDOI
Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors
Akila Jayaraman,Xiaoying Koh,Jing Li,Rahul Raman,Karthik Viswanathan,Zachary Shriver,Ram Sasisekharan +6 more
TL;DR: It was demonstrated that one such conserved glycosylation site at Asn91 in H1N1 HA critically governs the glycan receptor-binding specificity and hence would potentially impinge on the host adaptation of the virus.
Journal ArticleDOI
Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic
Kannan Tharakaraman,Rahul Raman,Nathan W. Stebbins,Karthik Viswanathan,Viswanathan Sasisekharan,Ram Sasisekharan +5 more
TL;DR: Using HA sequence features relevant to immune recognition, receptor binding and transmission, several recent H3 strains in avian and swine that present hallmarks of a reemerging virus are identified suggesting that existing vaccines may not be effective in protecting against these strains.
Journal ArticleDOI
VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro and in vivo.
Tengteng Yu,Tengteng Yu,Bharat Chaganty,Liang Lin,Lijie Xing,Boopathy Ramakrishnan,Kenneth Wen,Phillip A Hsieh,Andrew M. Wollacott,Karthik Viswanathan,Hedy Adari,Shih-Feng Cho,Shih-Feng Cho,Yuyin Li,Yuyin Li,Hailin Chen,Hailin Chen,Wenjuan Yang,Yan Xu,Yan Xu,Gang An,Lugui Qiu,Nikhil C. Munshi,Gregory J. Babcock,Zachary Shriver,James R. Myette,Kenneth C. Anderson,Yu-Tzu Tai +27 more
TL;DR: Clinical development of VIS832, alone and in combination, for the therapeutic treatment of MM in relapsed and refractory patients is supported while pointing to its potential therapeutic use earlier in disease intervention.
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Antibody-Bactericidal Macrocyclic Peptide Conjugates To Target Gram-Negative Bacteria.
Faycal Touti,Guillaume Lautrette,Kenneth D. Johnson,James C. Delaney,Andrew M. Wollacott,Hamid Tissire,Karthik Viswanathan,Zachary Shriver,Surin K. Mong,Alexander J. Mijalis,Obadiah Joseph Plante,Bradley L. Pentelute +11 more
TL;DR: In this paper, the authors developed antibody-bactericidal macrocyclic peptide conjugates (ABCs), in which the antibody directs the bioactive macrocyclicity peptide to the targeted Gram-negative bacteria and found that these ABCs had minimized hemolytic activity and were able to kill E coli at nanomolar concentrations.
Journal ArticleDOI
Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin.
TL;DR: It is shown that α2→6 glycan receptor-binding affinity of a mutant H9 HA carrying Thr-189→Ala amino acid change correlates with the respiratory droplet transmission in ferrets conferred by this change.