R
Ram Sasisekharan
Researcher at Massachusetts Institute of Technology
Publications - 316
Citations - 20441
Ram Sasisekharan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Hemagglutinin (influenza) & Heparan sulfate. The author has an hindex of 75, co-authored 306 publications receiving 19266 citations. Previous affiliations of Ram Sasisekharan include Singapore–MIT alliance & University of Toronto.
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Journal ArticleDOI
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Shiladitya Sengupta,David A. Eavarone,Ishan Capila,Ganlin Zhao,Nicki Watson,Tanyel Kiziltepe,Ram Sasisekharan +6 more
TL;DR: The disease-driven engineering of a drug delivery system, a ‘nanocell’, which overcomes barriers unique to solid tumours and results in improved therapeutic index with reduced toxicity, enabling the model of an ‘integrative’ approach in cancer therapy.
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Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice
Taronna R. Maines,Akila Jayaraman,Jessica A. Belser,Debra A. Wadford,Claudia Pappas,Hui Zeng,Kortney M. Gustin,Melissa B. Pearce,Karthik Viswanathan,Zachary Shriver,Rahul Raman,Nancy J. Cox,Ram Sasisekharan,Jacqueline M. Katz,Terrence M. Tumpey +14 more
TL;DR: In this paper, selected 2009 A(H1N1) influenza isolates were assessed for their ability to cause disease in mice and ferrets and compared with a contemporary seasonal H 1N1 virus for the ability to transmit to naive ferrets through respiratory droplets.
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Roles of heparan-sulphate glycosaminoglycans in cancer
TL;DR: Clinical trials are examining the anticancer properties of exogenous highly sulphated HSGAGs, including heparin and low-molecular-weight heparins, in addition to small oligosaccharideheparin mimetics.
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Contaminated heparin associated with adverse clinical events and activation of the contact system.
Takashi Kei Kishimoto,Karthik Viswanathan,Tanmoy Ganguly,Subbiah Elankumaran,Sean W. Smith,Kevin D. Pelzer,Jonathan C. Lansing,Nammalwar Sriranganathan,Ganlin Zhao,Zoya Galcheva-Gargova,Ali Al-Hakim,Gregory Scott Bailey,Blair A. Fraser,Sucharita Roy,Thomas Rogers-Cotrone,Lucinda F. Buhse,Mark T. Whary,James G. Fox,Moheb Nasr,Gerald J. Dal Pan,Zachary Shriver,Robert Langer,Ganesh Venkataraman,K. Frank Austen,Janet Woodcock,Ram Sasisekharan +25 more
TL;DR: An assay to assess the amidolytic activity of kallikrein can supplement analytic tests to protect the heparin supply chain by screening for OSCS and other highly sulfated polysaccharide contaminants of hepar in that can activate the contact system.
Journal ArticleDOI
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Marco Guerrini,Daniela Beccati,Zachary Shriver,Annamaria Naggi,Karthik Viswanathan,Antonella Bisio,Ishan Capila,Jonathan C. Lansing,Sara Guglieri,Blair A. Fraser,Ali Al-Hakim,Nur Sibel Gunay,Zhenqing Zhang,Luke Robinson,Lucinda F. Buhse,Moheb Nasr,Janet Woodcock,Robert Langer,Ganesh Venkataraman,Robert J. Linhardt,Benito Casu,Giangiacomo Torri,Ram Sasisekharan +22 more
TL;DR: Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.