K
Karuna P. Karunakaran
Researcher at University of British Columbia
Publications - 30
Citations - 1342
Karuna P. Karunakaran is an academic researcher from University of British Columbia. The author has contributed to research in topics: Antigen & Chlamydia trachomatis. The author has an hindex of 20, co-authored 30 publications receiving 1238 citations.
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Journal ArticleDOI
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus.
Raymond H. See,Alexander N. Zakhartchouk,Martin Petric,David Lawrence,Catherine P. Y. Mok,Robert J. Hogan,Thomas Rowe,Lois A. Zitzow,Karuna P. Karunakaran,Mary Hitt,Frank L. Graham,Ludvik Prevec,James B. Mahony,Chetna Sharon,Thierry C. Auperin,James M. Rini,Aubrey J. Tingle,David W. Scheifele,Danuta M. Skowronski,David M. Patrick,Thomas G. Voss,Lorne A. Babiuk,Jack Gauldie,Rachel L. Roper,Robert C. Brunham,B. Brett Finlay +25 more
TL;DR: The whole killed virus (WKV) vaccine given subcutaneously to 129S6/SvEv mice was more effective than the Ad S/N vaccine administered either intranasally or intramuscularly in inhibiting SARS-CoV replication in the murine respiratory tract.
Journal ArticleDOI
Immunoepidemiologic Profile of Chlamydia trachomatis Infection: Importance of Heat-Shock Protein 60 and Interferon-γ
Craig R. Cohen,Kasra M. Koochesfahani,Amalia Meier,Amalia Meier,Caixia Shen,Karuna P. Karunakaran,Beartrice Ondondo,Teresa Kinyari,Nelly Mugo,Rosemary Nguti,Robert C. Brunham +10 more
TL;DR: It is found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon- gamma by peripheral-blood mononuclear cells stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection.
Journal ArticleDOI
Immunoproteomic Discovery of Novel T Cell Antigens from the Obligate Intracellular Pathogen Chlamydia
Karuna P. Karunakaran,Jose Rey-Ladino,Nikolay Stoynov,Kyra B. Berg,Caixia Shen,Xiaozhou Jiang,Brent R. Gabel,Hong Yu,Leonard J. Foster,Robert C. Brunham +9 more
TL;DR: This study used a combination of affinity chromatography and tandem mass spectrometry to identify 13 Chlamydia peptides among 331 self-peptides presented by MHC class II (I-Ab) molecules from bone marrow-derived murine dendritic cells infected with Chlam Lydia muridarum.
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Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon (IFN-γ)/Tumor Necrosis Factor Alpha and IFN-γ/Interleukin-17 Double-Positive CD4+ T Cells
Hong Yu,Xiaozhou Jiang,Caixia Shen,Karuna P. Karunakaran,Janina Jiang,Nicole L. Rosin,Robert C. Brunham +6 more
TL;DR: A Chlamydia vaccine based on the recombinant proteins PmpG-1, PmpE/F-2, and MOMP delivered in a DDA/TDB adjuvant conferred protection against infection that correlated with IFN-γ/TNF-α and IFN -γ/IL-17 double-positive CD4+ T cells.
Journal ArticleDOI
Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines.
Raymond H. See,Martin Petric,David Lawrence,Catherine P. Y. Mok,Thomas Rowe,Lois A. Zitzow,Karuna P. Karunakaran,Thomas G. Voss,Robert C. Brunham,Jack Gauldie,B. Brett Finlay,Rachel L. Roper +11 more
TL;DR: A comparative evaluation of two SARS vaccines for their ability to protect against live SARS-CoV intranasal challenge in ferrets suggests that a combination of vaccine strategies may be required for effective protection from this pathogen.