Robert J. Hogan

TL;DR: It is demonstrated that immunization of mice with synthetic nanoparticles containing antigens plus ligands that signal through TLR4 and TLR7 induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with nanoparticles minus a single TLR ligand, and there was enhanced persistence of germinal centres and of plasma-cell responses, which persisted in the lymph nodes for >1.5 years.

TL;DR: A substantial population of Ag-specific CD8+ T cells in the lung that persist for several months after recovery from an influenza or Sendai virus infection is identified.

TL;DR: Vaccination of mice with influenza matrix protein 2 induced cross-reactive antibody responses and this data indicates that vaccination with this protein increases the likelihood of antibody responses to influenza.

TL;DR: Preclinical experiments reveal 4 (PF-00835231) as a potent inhibitor of CoV-2 3CLpro with suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.

TL;DR: It is demonstrated that virus-specific CD4+ T cells persist in the lung tissues and airways for several months after Sendai virus infection of C57BL/6 mice and that activated memory CD4- T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity.