K
Katarina Pettersson
Researcher at Karolinska Institutet
Publications - 19
Citations - 5001
Katarina Pettersson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Estrogen receptor & Estrogen receptor beta. The author has an hindex of 18, co-authored 19 publications receiving 4811 citations.
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Journal ArticleDOI
Mechanisms of Estrogen Action
Stefan Nilsson,Sari Mäkelä,Eckardt Treuter,Michel Tujague,Jane S. Thomsen,Göran Andersson,Eva Enmark,Katarina Pettersson,Margaret Warner,Jan-Åke Gustafsson +9 more
TL;DR: The role of estrogen receptors in physiology and pathology has been investigated in the past decade and it was found that there was not one but two distinct and functional estrogen receptors, now called ERα and ERβ.
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Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha.
TL;DR: The cloning of the cDNA encoding the mouse homolog of estrogen receptor-beta (ER beta) and the functional characterization of mouse ER beta protein suggest the existence of two previously unrecognized pathways of estrogen signaling; I, via ER beta in cells exclusively expressing this subtype, and II, via the formation of heterodimers in cells expressing both receptor subtypes.
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Role of estrogen receptor beta in estrogen action
TL;DR: This review focuses on the mechanistic aspects of signal transduction mediated by ERs and on the physiological consequences of deficiency of estrogen or estrogen receptor in the available mouse models.
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Estrogen receptor β acts as a dominant regulator of estrogen signaling
TL;DR: It is shown that co-localization and subsequent heterodimerization of ERα and ERβ may result in receptor activity distinct from that of ER homodimers, and that ERβ can act as a negative or positive dominant regulator of ER activity.
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Transcriptional targets shared by estrogen receptor‐related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ
TL;DR: Analysis of the cross‐talk within the ER/ERR subgroup of nuclear receptors thus revealed common targets but also functional differences between the two ERs.