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Eva Enmark
Researcher at Karolinska Institutet
Publications - 24
Citations - 15398
Eva Enmark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Estrogen receptor beta & Estrogen receptor. The author has an hindex of 18, co-authored 24 publications receiving 15012 citations.
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Journal ArticleDOI
Cloning of a novel receptor expressed in rat prostate and ovary.
TL;DR: It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
Journal ArticleDOI
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
George G.J.M. Kuiper,Bo Carlsson,Kaj Grandien,Eva Enmark,Johan Häggblad,Stefan K. Nilsson,Jan-Åke Gustafsson +6 more
TL;DR: The messenger RNA expression of both ER subtypes in rat tissues by RT-PCR is investigated and the ligand binding specificity of the ER sub types is compared, revealing a single binding component for 16β-estradiol with high affinity.
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Mechanisms of Estrogen Action
Stefan Nilsson,Sari Mäkelä,Eckardt Treuter,Michel Tujague,Jane S. Thomsen,Göran Andersson,Eva Enmark,Katarina Pettersson,Margaret Warner,Jan-Åke Gustafsson +9 more
TL;DR: The role of estrogen receptors in physiology and pathology has been investigated in the past decade and it was found that there was not one but two distinct and functional estrogen receptors, now called ERα and ERβ.
Journal ArticleDOI
Generation and reproductive phenotypes of mice lacking estrogen receptor β
John H. Krege,Jeffrey B. Hodgin,John F. Couse,Eva Enmark,Margaret Warner,Joel F. Mahler,Madhabananda Sar,Kenneth S. Korach,Jan-Åke Gustafsson,Oliver Smithies +9 more
TL;DR: The generation of mice lacking estrogen receptor beta (ERbeta -/-) is described by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous recombination in embryonic stem cells to determine the role of ERbeta in bone and cardiovascular homeostasis.
Journal ArticleDOI
Cloning and Expression of a Novel Mammalian Thioredoxin
TL;DR: A 1276-base pair cDNA from a rat heart cDNA library that encodes a novel thioredoxin (Trx2) of 166 amino acid residues with a calculated molecular mass of 18.2 kDa possessed a dithiol-reducing enzymatic activity and was able to reduce the interchain disulfide bridges of insulin.