K
Katarzyna Grychowska
Researcher at Jagiellonian University Medical College
Publications - 22
Citations - 321
Katarzyna Grychowska is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: 5-HT6 receptor & Inverse agonist. The author has an hindex of 8, co-authored 19 publications receiving 231 citations. Previous affiliations of Katarzyna Grychowska include Centre national de la recherche scientifique.
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Journal ArticleDOI
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline- sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors
Paweł Zajdel,Krzysztof Marciniec,Andrzej Maślankiewicz,Katarzyna Grychowska,Grzegorz Satała,Beata Duszyńska,Tomasz Lenda,Agata Siwek,Gabriel Nowak,Anna Partyka,Dagmara Wróbel,Magdalena Jastrzębska-Więsek,Andrzej J. Bojarski,Anna Wesołowska,Maciej Pawłowski +14 more
TL;DR: A series of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole was synthesized to explore the influence of two structural features - replacement of ether/amide moiety with sulfonamide one, and localization of a sulf onamide group in the azine moiety.
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Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease.
Katarzyna Grychowska,Grzegorz Satała,Tomasz Kos,Anna Partyka,Evelina Colacino,Séverine Chaumont-Dubel,Xavier Bantreil,Anna Wesołowska,Maciej Pawłowski,Jean Martinez,Philippe Marin,Gilles Subra,Andrzej J. Bojarski,Frédéric Lamaty,Piotr Popik,Paweł Zajdel +15 more
TL;DR: The design, synthesis, and characterization of a novel class of 5-HT6R antagonists that is based on the 1H-pyrrolo[3,2-c]quinoline core are reported, and results are promising enough to warrant further detailed mechanistic studies on the therapeutic potential of5-HT 6R antagonists and inverse agonists for the treatment of cognitive decline and depression/anxiety symptoms that are comorbidities of Alzheimer's disease.
Journal ArticleDOI
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists
Paweł Zajdel,Rafał Kurczab,Katarzyna Grychowska,Grzegorz Satała,Maciej Pawłowski,Andrzej J. Bojarski +5 more
TL;DR: The study allowed us to identify compound 68 (4-fluoro-N-(1-{2-[(propan-2-yl]ethyl}piperidin-4-yl) benzenesulfonamide) as a potent 5-HT(7)R ligand with strong antagonistic properties and a 1450-fold selectivity over 5- HT(1A)Rs.
Journal ArticleDOI
Dual 5-HT 6 and D 3 Receptor Antagonists in a Group of 1 H -Pyrrolo[3,2- c ]quinolines with Neuroprotective and Procognitive Activity
Katarzyna Grychowska,Séverine Chaumont-Dubel,Rafał Kurczab,Paulina Koczurkiewicz,Caroline Deville,Martyna Krawczyk,Wojciech Pietruś,Grzegorz Satała,Szymon Buda,Kamil Piska,Marcin Drop,Xavier Bantreil,Frédéric Lamaty,Elżbieta Pękala,Andrzej J. Bojarski,Piotr Popik,Philippe Marin,Paweł Zajdel +17 more
TL;DR: Biological results obtained for compound 19, obtained in in vitro tests, translated into procognitive properties in phencyclidine (PCP)-induced memory decline in the novel object recognition (NOR) task in rats.
Journal ArticleDOI
Continuous flow ring-closing metathesis, an environmentally-friendly route to 2,5-dihydro-1H-pyrrole-3-carboxylates
Marcin Drop,Xavier Bantreil,Katarzyna Grychowska,Gilbert Umuhire Mahoro,Evelina Colacino,Maciej Pawłowski,Jean Martinez,Gilles Subra,Paweł Zajdel,Frédéric Lamaty +9 more
TL;DR: In this article, the use of continuous flow allowed a key synthetic step, namely ruthenium-catalyzed ring-closing metathesis, with a residence time of 1 min at 120 °C.