Charles Girardot

TL;DR: This new approach to obtain cell type–specific information on chromatin state and RNA polymerase II (Pol II) occupancy within the multicellular Drosophila melanogaster embryo identifies dynamic enhancer usage, an essential step in deciphering developmental networks.

TL;DR: A novel approach to predict spatio-temporal cis-regulatory activity based only on in vivo transcription factor binding and enhancer activity data is used, generating a high-resolution atlas of cis-Regulatory modules describing their temporal and combinatorial occupancy during Drosophila mesoderm development.

TL;DR: It is suggested that Twist binds to almost all mesodermal CRMs to provide the competence to integrate inputs from more specialized transcription factors, and extensive combinatorial binding, feed-forward regulation, and complex logical outputs as prevalent features are revealed.

TL;DR: It is demonstrated that the five genetic components essential for cardiac specification in Drosophila, including the effectors of Wg and Dpp signaling, act as a collective unit to cooperatively regulate heart enhancer activity, both in vivo and in–vitro.

TL;DR: In this article, genome-wide binding profiles of PhoRC, the Drosophila PcG protein complex containing the DNA-binding factor Pho/dYY1 and dSfmbt were reported.