Katarzyna Rolle

TL;DR: This work found that the mRNAs of hilD (master regulator of the SPI-1 invasion genes) and flhDC (flagellar master regulator) were bound by Hfq, and presented a generic strategy that is ideal for the systems-level analysis of the post-transcriptional regulons of RNA-binding proteins and for sRNA discovery in a wide range of bacteria.

TL;DR: Evidence is provided of a conserved inherent sRNA-binding property of Hfq, which may facilitate the lateral transmission of regulatory sRNAs among distantly related species and suggests that the expression of heterologous RNA-binding proteins combined with deep sequencing analysis of RNA ligands can be used as a molecular tool to dissect individual steps of RNA metabolism in vivo.

TL;DR: The meta‐analysis of miRNA profiling studies in GBM tissues summarizes the past and recent advances in the investigation of the miRNA signature in G BM versus noncancerous human brain and provides a comprehensive overview.

TL;DR: Directed knockdown of matR expression via synthetically designed ribozymes altered the processing of various introns, including nad1 i4, suggesting that MatR may represent an intermediate link in the gradual evolutionary transition from the intron-specific maturases in bacteria into their versatile spliceosomal descendants in the nucleus.

TL;DR: It was found that the intensity of TN-C staining correlates with the tumor grade and that the strongest staining indicates poor prognosis, and for the first time RNA interference technology was applied, to suppress human brain tumors through inhibition of the synthesis of tenascin-C.