K
Kate Powell
Researcher at Cardiff University
Publications - 16
Citations - 619
Kate Powell is an academic researcher from Cardiff University. The author has contributed to research in topics: Population & Retinal ganglion. The author has an hindex of 10, co-authored 16 publications receiving 409 citations. Previous affiliations of Kate Powell include University of Oxford & University of Otago.
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Journal ArticleDOI
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
Tianqi Leng,Hossain Delowar Akther,Hackstein C-P.,Kate Powell,Thomas C. King,Matthias Friedrich,Zoe Christoforidou,Sarah McCuaig,Mastura Neyazi,Carolina V. Arancibia-Cárcamo,Joachim Hagel,Fiona Powrie,Raphael S. Peres,Val Millar,Daniel Ebner,Rajesh Lamichhane,James E. Ussher,Hinks Tsc.,Emanuele Marchi,Christian B. Willberg,Paul Klenerman,Paul Klenerman +21 more
TL;DR: Data indicate the blend of T CR-dependent and TCR-independent signaling to CD8+ MAIT cells may play a role in controlling the balance between healthy and pathological processes of tissue inflammation and repair.
Journal ArticleDOI
Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides
Lydia C. Powell,Manon F. Pritchard,Elaine Lesley Ferguson,Kate Powell,Shree U. Patel,Phil D. Rye,Stavroula-Melina Sakellakou,Niklaas J. Buurma,Charles D. Brilliant,Jack M. Copping,Georgina E. Menzies,Paul D. Lewis,Katja E. Hill,David Thomas +13 more
TL;DR: The ability of OligoG to diffuse into biofilms, potentiate antibiotic activity, disrupt DNA-Ca2+-DNA bridges and biofilm EPS matrix highlights its potential for the treatment of biofilm-related infections.
Journal ArticleDOI
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness.
Manon F. Pritchard,Lydia C. Powell,Alison A. Jack,Kate Powell,Konrad Beck,Hannah Florance,Julian Forton,Philip D. Rye,Arne Dessen,Katja E. Hill,David Thomas +10 more
TL;DR: Findings reinforce the potential clinical significance of microcolony formation in the CF lung and highlight a novel approach to treat MDR pseudomonal infections.
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Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus.
Maria Diez-Ortiz,Elma Lahive,Peter Kille,Kate Powell,A. John Morgan,Kerstin Jurkschat,Cornelis A.M. van Gestel,J. Fred W. Mosselmans,Claus Svendsen,David J. Spurgeon +9 more
TL;DR: The importance of oral exposure questions the application of current metal bioavailability models, which implicitly consider that the dominant route of exposure is via the soil solution, for bioavailability assessment and modeling of metal-based NPs.
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Analytical approaches to support current understanding of exposure, uptake and distributions of engineered nanoparticles by aquatic and terrestrial organisms
Carolin L. Schultz,Kate Powell,Alison Crossley,Kerstin Jurkschat,Peter Kille,A. John Morgan,Daniel S. Read,William Tyne,Elma Lahive,Claus Svendsen,David J. Spurgeon +10 more
TL;DR: The first decade of ENP ecotoxicology research points to an emerging paradigm where exposure is to transformed materials transported into tissues and cells via passive and active pathways within which they can be assimilated and therein identified using a tiered analytical and imaging approach.