K
Katelyn. J. Kozma
Researcher at University of Toronto
Publications - 6
Citations - 58
Katelyn. J. Kozma is an academic researcher from University of Toronto. The author has contributed to research in topics: Invasive lobular carcinoma & Breast cancer. The author has an hindex of 2, co-authored 5 publications receiving 32 citations. Previous affiliations of Katelyn. J. Kozma include Hospital for Sick Children.
Papers
More filters
Journal ArticleDOI
Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Yeji An,Jessica R. Adams,Daniel P. Hollern,Anthony Zhao,Stephen Chang,Miki S. Gams,Philip E.D. Chung,Philip E.D. Chung,Xiaping He,Rhea Jangra,Juhi S. Shah,Joanna Yang,Lauren A. Beck,Nandini Raghuram,Katelyn. J. Kozma,Amanda J. Loch,Wei Wang,Cheng Fan,Susan J. Done,Susan J. Done,Eldad Zacksenhaus,Eldad Zacksenhaus,Cynthia J. Guidos,Charles M. Perou,Sean E. Egan +24 more
TL;DR: It is reported that deletion of Cdh1, together with activation of Pik3ca in mammary epithelium of genetically modified mice, leads to formation of IR-ILC-like tumors with immune cell infiltration, as well as gene expression linked to T-regulatory (Treg) cell signaling and activation of targetable immune checkpoint pathways.
Journal ArticleDOI
The tumor cell-derived matrix of lobular breast cancer: a new vulnerability.
TL;DR: Sflomos et al. as mentioned in this paper used an intraductal injection-based xenograft system to identify novel tumor cell-specific transcriptional signatures in invasive lobular carcinoma (ILC).
Journal ArticleDOI
Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.
Nathan F. Schachter,Jessica R. Adams,Patryk Skowron,Katelyn. J. Kozma,Christian A. Lee,Christian A. Lee,Nandini Raghuram,Joanna Yang,Amanda J. Loch,Wei Wang,Aaron Kucharczuk,Katherine L. Wright,Rita M. Quintana,Yeji An,Daniel Dotzko,Jennifer L. Gorman,Daria Wojtal,Juhi S. Shah,Paul Leon-Gomez,Giovanna Pellecchia,Adam J. Dupuy,Charles M. Perou,Ittai Ben-Porath,Rotem Karni,Eldad Zacksenhaus,Eldad Zacksenhaus,James R. Woodgett,James R. Woodgett,Susan J. Done,Livia Garzia,Livia Garzia,A. Sorana Morrissy,A. Sorana Morrissy,Jüri Reimand,Jüri Reimand,Michael D. Taylor,Sean E. Egan +36 more
TL;DR: The authors identified 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC and highlighted a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.
Journal ArticleDOI
Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer.
Ellen Langille,Khalid N. Al-Zahrani,Zhibo Ma,Minggao Liang,Liis Uuskula-Reimand,Roderic Espín,Katie Teng,Ahmad Malik,Helga Bergholtz,Samah El Ghamrasni,Somaieh Afiuni-Zadeh,Ricky Tsai,Sana Alvi,Andrew J. Elia,Yiqing Lu,Robin H. Oh,Katelyn. J. Kozma,Dan Trcka,Masahiro Narimatsu,Jeff C. Liu,Thomas Nguyen,Seda Avcioglu Barutcu,Sampath K. Loganathan,Rod Bremner,Gary D. Bader,Sean E. Egan,David W. Cescon,Therese Sørlie,Jeffrey L. Wrana,Hartland W. Jackson,Michael D. Wilson,Agnieszka K. Witkiewicz,Erik S. Knudsen,Miguel Angel Pujana,Geoff Wahl,Daniel Schramek +35 more
TL;DR: A somatic CRISPR/Cas9 mutagenesis screen to study 215 recurrent 'long-tail' breast cancer genes revealed epigenetic regulation as a major tumor suppressive mechanism, suggesting a basal origin for luminal tumors.
Posted ContentDOI
Loss of epigenetic regulation disrupts lineage integrity, reactivates multipotency and promotes breast cancer
Ellen Langille,Ellen Langille,Khalid N Al-Zahrani,Zhibo Ma,Ahmad Malik,Ahmad Malik,Sampath Kumar Loganathan,Dan Trcka,Jeff C. Liu,Katelyn. J. Kozma,Katelyn. J. Kozma,Ricky Tsai,Katie Teng,Katie Teng,Roderic Espín,Seda Barutcu,Thomas Nguyen,Thomas Nguyen,Rod Bremner,Hartland W. Jackson,Hartland W. Jackson,Erik S. Knudsen,Gary D. Bader,Sean E. Egan,Miquel Angel Pujana,Jeff Wrana,Jeff Wrana,Geoffrey M. Wahl,Daniel Schramek,Daniel Schramek +29 more
TL;DR: In this article, the core or accessory components of the COMPASS histone methylase complex including KMT2C, KDM6A, BAP1 and ASXL2 (EpiDrivers) cooperate with PIK3CAH1047R to transform mouse and human breast epithelial cells.