Katherine Drews-Elger

TL;DR: High-VEGF tumors may be most likely to escape anti-angiogenics by upregulating VEGF, driving CSC self-renewal to re-populate post-treatment, and highlights the need to better define V EGF-driven cancer subsets and supports further investigation of combined therapeutic blockade of VEGFR-2 and JAK2/STAT3.

TL;DR: A novel in vivo model using human breast cancer xenografts in NOD scid gamma (NSG) mice enables the study of the entire metastatic process from the proper anatomical site, providing an important new approach to examine the mechanisms underlying breast cancer metastasis.

TL;DR: These data support a model in which cancer cell invasion into local fat would establish feed-forward loops to activate Src, maintain proinflammatory cytokine production, and increase tumor-initiating cell abundance and metastatic progression.

TL;DR: It is demonstrated that RAGE drives tumor progression and metastasis through distinct tumor cell-intrinsic and -extrINSic mechanisms, and may represent a novel and therapeutically viable approach for treating metastatic cancers.

TL;DR: An overview of Paget’s disease of the breast with special attention to immunohistochemistry is provided and the question of new therapeutic approaches is raised.