Jun Sun

TL;DR: The data indicate that phosphorylation by Src impairs the Cdk2 inhibitory action of p27 and reduces its steady-state binding to cyclin E-Cdk2-dependent p27 proteolysis, and this provides a new rationale for Src inhibitors in cancer therapy.

TL;DR: High-VEGF tumors may be most likely to escape anti-angiogenics by upregulating VEGF, driving CSC self-renewal to re-populate post-treatment, and highlights the need to better define V EGF-driven cancer subsets and supports further investigation of combined therapeutic blockade of VEGFR-2 and JAK2/STAT3.

TL;DR: An oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) recruitment and activation is described.

TL;DR: It is demonstrated that WBP-2 and E6-associated protein each enhance PR function, and their effect on PR action are additive when coexpressed, suggesting a common signaling pathway.

TL;DR: The results indicate that Src cooperates with estrogen to activate ERα proteolysis, and support a model whereby crosstalk between liganded ERα and Src drives ERα transcriptional activity and targets ERα for ubiquitin-dependent proteolytic activity.