K
Katherine Gowan
Researcher at University of Colorado Denver
Publications - 42
Citations - 3565
Katherine Gowan is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Vitiligo & Single-nucleotide polymorphism. The author has an hindex of 25, co-authored 41 publications receiving 3018 citations. Previous affiliations of Katherine Gowan include Anschutz Medical Campus & University of Colorado Boulder.
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Journal ArticleDOI
NALP1 in Vitiligo-Associated Multiple Autoimmune Disease
Ying Jin,Christina M. Mailloux,Katherine Gowan,Sheri L. Riccardi,Greggory S. LaBerge,Dorothy C. Bennett,Pamela R. Fain,Richard A. Spritz +7 more
TL;DR: DNA sequence variants in the NALP1 region are associated with the risk of several epidemiologically associated autoimmune and autoinflammatory diseases, implicating the innate immune system in the pathogenesis of these disorders.
Journal ArticleDOI
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
Ying Jin,Stanca A. Birlea,Pamela R. Fain,Katherine Gowan,Sheri L. Riccardi,Paulene J. Holland,Christina M. Mailloux,Alexandra Sufit,Saunie M. Hutton,Anita Amadi-Myers,Dorothy C. Bennett,Margaret R. Wallace,Wayne T. McCormack,E. Helen Kemp,David J. Gawkrodger,Anthony P. Weetman,Mauro Picardo,Giovanni Leone,Alain Taieb,Thomas Jouary,Khaled Ezzedine,Nanny van Geel,Jo Lambert,Andreas Overbeck,Richard A. Spritz +24 more
TL;DR: In this article, a genomewide association study was conducted to identify generalized vitiligo susceptibility loci, where 579,146 single-nucleotide polymorphisms (SNPs) were found in 1514 patients with generalized vitilligo who were of European-derived white ancestry and compared the genotypes with publicly available control genotypes from 2813 CEU persons.
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Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
Ying Jin,Stanca A. Birlea,Pamela R. Fain,Tracey M. Ferrara,Songtao Ben,Sheri L. Riccardi,Joanne B. Cole,Katherine Gowan,Paulene J. Holland,Dorothy C. Bennett,Rosalie M. Luiten,Albert Wolkerstorfer,J.P. Wietze van der Veen,A. Hartmann,Saskia Eichner,Gerold Schuler,Nanja van Geel,Jo Lambert,E. Helen Kemp,David J. Gawkrodger,Anthony P. Weetman,Alain Taieb,Thomas Jouary,Khaled Ezzedine,Margaret R. Wallace,Wayne T. McCormack,Mauro Picardo,Giovanni Leone,Andreas Overbeck,Nanette B. Silverberg,Nanette B. Silverberg,Richard A. Spritz +31 more
TL;DR: Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among Vitiligo, melanoma, and eye, skin and hair coloration.
Journal ArticleDOI
Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia
Leila Noetzli,Richard W. Lo,Alisa B. Lee-Sherick,Michael U. Callaghan,Patrizia Noris,Anna Savoia,Madhvi Rajpurkar,Kenneth L. Jones,Katherine Gowan,Carlo L. Balduini,Alessandro Pecci,Chiara Gnan,Daniela De Rocco,Michael Doubek,Ling Li,Lily Lu,Richard S. Leung,Carolina Landolt-Marticorena,Stephen P. Hunger,Paula G. Heller,Arthur Gutierrez-Hartmann,Liang Xiayuan,Fred G. Pluthero,Jesse W. Rowley,Andrew S. Weyrich,Walter H. A. Kahr,Christopher C. Porter,Jorge Di Paola +27 more
TL;DR: This article identified a family with autosomal dominant thrombocytopenia, high erythrocyte mean corpuscular volume (MCV) and two occurrences of B cell-precursor acute lymphoblastic leukemia (ALL).
Journal ArticleDOI
NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome
Cecilia B. Levandowski,Christina M. Mailloux,Tracey M. Ferrara,Katherine Gowan,Songtao Ben,Ying Jin,Kimberly K. McFann,Paulene J. Holland,Pamela R. Fain,Charles A. Dinarello,Richard A. Spritz +10 more
TL;DR: Nuclear localization leucine-rich-repeat protein 1 (NLRP1) RNA and protein levels were not altered by the predominant high-risk haplotype, indicating that altered function of the corresponding multivariant NLRP1 polypeptide predisposes to autoimmune diseases by activation of the NL RP1 inflammasome.