J
Joanne B. Cole
Researcher at Broad Institute
Publications - 52
Citations - 2148
Joanne B. Cole is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 14, co-authored 38 publications receiving 1075 citations. Previous affiliations of Joanne B. Cole include Harvard University & University of Colorado Denver.
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Journal ArticleDOI
Genetics of diabetes mellitus and diabetes complications.
TL;DR: Advances in genomic analysis are described that have enabled novel genetic discoveries, more than doubled the number of genetic loci associated with type 2 diabetes mellitus and uncovered several novel candidate genes for diabetes complications.
Journal ArticleDOI
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.
Miriam S. Udler,Jaegil Kim,Marcin von Grotthuss,Sílvia Bonàs-Guarch,Joanne B. Cole,Joanne B. Cole,Joshua Chiou,Michael Boehnke,Markku Laakso,Markku Laakso,Gil Atzmon,Benjamin Glaser,Josep M. Mercader,Kyle J. Gaulton,Kyle J. Gaulton,Jason Flannick,Gad Getz,Jose C. Florez +17 more
TL;DR: The approach identifies salient T2D genetically anchored and physiologically informed pathways, and supports the use of genetics to deconstruct T1D heterogeneity.
Journal ArticleDOI
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
Ying Jin,Stanca A. Birlea,Pamela R. Fain,Tracey M. Ferrara,Songtao Ben,Sheri L. Riccardi,Joanne B. Cole,Katherine Gowan,Paulene J. Holland,Dorothy C. Bennett,Rosalie M. Luiten,Albert Wolkerstorfer,J.P. Wietze van der Veen,A. Hartmann,Saskia Eichner,Gerold Schuler,Nanja van Geel,Jo Lambert,E. Helen Kemp,David J. Gawkrodger,Anthony P. Weetman,Alain Taieb,Thomas Jouary,Khaled Ezzedine,Margaret R. Wallace,Wayne T. McCormack,Mauro Picardo,Giovanni Leone,Andreas Overbeck,Nanette B. Silverberg,Nanette B. Silverberg,Richard A. Spritz +31 more
TL;DR: Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among Vitiligo, melanoma, and eye, skin and hair coloration.
Journal ArticleDOI
Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology
John R. Shaffer,Ekaterina Orlova,Myoung Keun Lee,Elizabeth J. Leslie,Zachary D. Raffensperger,Carrie L. Heike,Michael L. Cunningham,Jacqueline T. Hecht,Chung How Kau,Nichole Nidey,Lina M. Moreno,George L. Wehby,Jeffrey C. Murray,Cecelia A. Laurie,Cathy C. Laurie,Joanne B. Cole,Tracey M. Ferrara,Stephanie A. Santorico,Ophir D. Klein,Washington Mio,Eleanor Feingold,Benedikt Hallgrímsson,Richard A. Spritz,Mary L. Marazita,Seth M. Weinberg +24 more
TL;DR: This paper conducted genome-wide association meta-analyses of 20 quantitative facial measurements derived from the 3D surface images of 3118 healthy individuals of European ancestry belonging to two US cohorts.
Journal ArticleDOI
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.
Rany M. Salem,Jennifer Todd,Jennifer Todd,Niina Sandholm,Joanne B. Cole,Joanne B. Cole,Wei-Min Chen,Darrell Andrews,Marcus G. Pezzolesi,Paul M. McKeigue,Linda T. Hiraki,Chengxiang Qiu,Viji Nair,Chen Di Liao,Jing Jing Cao,Erkka Valo,Suna Onengut-Gumuscu,Adam M. Smiles,Stuart J. McGurnaghan,Jani K. Haukka,Valma Harjutsalo,Eoin P. Brennan,Natalie R. van Zuydam,Emma Ahlqvist,Ross Doyle,Tarunveer S. Ahluwalia,Maria Lajer,Maria Hughes,Jihwan Park,Jan Skupien,Athina Spiliopoulou,Andrew C. Liu,Rajasree Menon,Carine M. Boustany-Kari,Hyun Min Kang,Robert G. Nelson,Ronald Klein,Barbara E.K. Klein,Kristine E. Lee,Xiaoyu Gao,Michael Mauer,Silvia Maestroni,Maria Luiza Caramori,Ian H. de Boer,Rachel G. Miller,Jingchuan Guo,Andrew P. Boright,David-Alexandre Trégouët,David-Alexandre Trégouët,Beata Gyorgy,Beata Gyorgy,Janet K. Snell-Bergeon,David M. Maahs,Shelley B. Bull,Angelo J. Canty,Colin N. A. Palmer,Lars Stechemesser,Bernhard Paulweber,Raimund Weitgasser,Jelizaveta Sokolovska,Vita Rovīte,Valdis Pīrāgs,Edita Prakapiene,Lina Radzeviciene,Rasa Verkauskiene,Nicolae Mircea Panduru,Nicolae Mircea Panduru,Leif Groop,Leif Groop,Mark I. McCarthy,Harvest F. Gu,Anna Möllsten,Henrik Falhammar,Henrik Falhammar,Kerstin Brismar,Kerstin Brismar,Finian Martin,Peter Rossing,Peter Rossing,Tina Costacou,Gianpaolo Zerbini,Michel Marre,Samy Hadjadj,Amy Jayne McKnight,Carol Forsblom,Gareth J. McKay,Catherine Godson,A. Peter Maxwell,Matthias Kretzler,Katalin Susztak,Helen M. Colhoun,Andrzej S. Krolewski,Andrew D. Paterson,Per-Henrik Groop,Stephen S. Rich,Joel N. Hirschhorn,Joel N. Hirschhorn,Jose C. Florez +97 more
TL;DR: In this paper, a large collection of type 1 diabetes cohorts with harmonized diabetic kidney disease phenotypes were assembled through collaboration with the Diabetes Nephropathy Collaborative Research Initiative, and 16 genome-wide significant risk loci were identified.