K
Katherine S. Long
Researcher at Technical University of Denmark
Publications - 28
Citations - 2191
Katherine S. Long is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: 23S ribosomal RNA & Peptidyl transferase. The author has an hindex of 20, co-authored 28 publications receiving 1963 citations. Previous affiliations of Katherine S. Long include University of Southern Denmark & University of Copenhagen.
Papers
More filters
Journal ArticleDOI
The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics
TL;DR: The findings described in this study represent the first report of a gene conferring transferable resistance to pleuromutilins and oxazolidinones and the phenotype is named PhLOPSA for resistance to the following drug classes.
Journal ArticleDOI
Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome
Katherine S. Long,Birte Vester +1 more
TL;DR: Detailed knowledge of the linezolid binding site has facilitated the design of a new generation of oxazolidinones that show improved properties against the known resistance mechanisms.
Journal ArticleDOI
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria.
Anders M.B. Giessing,Søren Skov Jensen,Anette Rasmussen,Lykke Haastrup Hansen,Andrzej Gondela,Katherine S. Long,Birte Vester,Finn Kirpekar +7 more
TL;DR: Analysis of RNA derived from E. coli strains lacking the m(2)A2503 methyltransferase reveals that Cfr also has the ability to catalyze methylation at position 2 to form 2,8-dimethyladenosine, the first instance where the 8-methyladenosines modification has been described in natural RNA molecules.
Journal ArticleDOI
Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.
TL;DR: Chemical footprinting experiments show a reduced binding of tiamulin to ribosomal subunits from mutants with decreased susceptibility to the drug, likely the resistance mechanism for these strains.
Journal ArticleDOI
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa
TL;DR: RNA-seq is used to identify novel transcripts in P.aeruginosa involving a combination of three different sequencing libraries, supporting a limited degree of sequence conservation and rapid evolution of sRNAs at the species level.