Finn Kirpekar

TL;DR: The sequence and the structure of DNA methyltransferase-2 (DnMT2) bear close affinities to authentic DNA cytosine methyltransferases, and human DNMT2 protein restored methylation in vitro to tRNAAsp from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.

TL;DR: A survey of ESI and MALDI mass spectrometric analysis of nucleic acid oligomers and polymers, dealing with the practical aspects of the two ionization techniques, fragmentation, and applications, respectively.

TL;DR: Matrix-assisted laser desorption/ionization (MALDI) mass spectra of synthetic DNA, restriction enzyme fragments of plasmid DNA, and RNA transcripts up to a size of 2180 nucleotides are reported, which surpass all currently available techniques for the analysis of large nucleic acids.

TL;DR: Experiments indicate that the breakage of the N-glycosidic bond probably occurs during the desorption process due to proton transfer from the phosphodiester groups to the ionizable bases.

TL;DR: It is shown here that ALKBh8 is a tRNA methyltransferase required for the final step in the biogenesis of mcm5U, and that the interaction of ALKBH8 with a small accessory protein, TRM112, is required to form a functional tRNAmethyltransferase.