Weimin Wang

TL;DR: Investigation of human transcriptomes before and during nivolumab therapy revealed that clinical benefits correlate with reduced expression of SLC3A2 and increased IFNγ and CD8 and targeting this pathway in combination with checkpoint blockade is a potential therapeutic approach.

TL;DR: Using human ovarian cancers as their model, this paper showed that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA methyltransferase 1 (DNMT1)-mediated DNA methylation repress the tumour production of T helper 1 (TH1)-type chemokines CXCL9 and CXCl10, and subsequently determine effector T-cell trafficking to the tumours microenvironment.

TL;DR: It is demonstrated that radiotherapy induces tumor cell ferroptosis, an unappreciated mechanism and focus for the development of effective combinatorial cancer therapy.

TL;DR: The data support a model wherein tumor Treg cells sustain and amplify their suppressor capacity through inadvertent death via oxidative stress and highlights the oxidative pathway as a metabolic checkpoint that controls Treg cell behavior and affects the efficacy of therapeutics targeting cancer checkpoints.

TL;DR: It is shown that fibroblasts diminish nuclear accumulation of platinum in ovarian cancer cells, resulting in resistance to platinum-based chemotherapy, and it is demonstrated that glutathione and cysteine released by fibro Blasts contribute to this resistance.