Kathleen Sprouffske

TL;DR: Growthcurver summarizes the growth characteristics of microbial growth curve experiments conducted in a plate reader and is an easy-to-use R package available for installation from the Comprehensive R Archive Network (CRAN).

TL;DR: It is argued that enhanced prediction and control of cancer may be possible using ideas developed in the context of experimental evolution, and some prospects for future research at the interface between these traditionally separate areas are pointed out.

TL;DR: TheN-methyl-d-aspartate (NMDA) receptor has been implicated in the formation of synaptic connections and the role of the e2 (NR2B) NMDA receptor subunit, which is prominently expressed, is investigated.

TL;DR: It is found that a mutation disrupting differentiation can create a new self-renewing cell population that is vulnerable to somatic evolution, which is relevant not only to the evolutionary origins of multicellularity, but also the causes of pathologies such as cancer and senescence in extant metazoans, including humans.

TL;DR: This work demonstrates that the mutation rate changes the global balance between deleterious and beneficial mutational effects on fitness, and suggests that this tipping point already occurs at the modest mutation rates that are found in the wild.