Kathryn A. Seely

TL;DR: A review of the legal status of common synthetic cannabinoids detected in Spice and analytical procedures used to test Spice products and human specimens collected under a variety of clinical circumstances is provided in this paper.

TL;DR: It is demonstrated that mRNA, receptor binding and function of CB2, but not CB1, receptors are dramatically and selectively up‐regulated in spinal cords of G93A‐SOD1 mice in a temporal pattern paralleling disease progression, and CB2 agonists may slow motor neuron degeneration and preserve motor function.

TL;DR: Test the hypothesis that JWH-018 and its fluorinated counterpart AM2201 are subject to cytochrome P450 (P450)-mediated oxidation, forming potent hydroxylated metabolites that retain significant affinity and activity at the cannabinoid 1 (CB1) receptor.

TL;DR: Resveratrol may have a dual mechanism of action to restore the renal microcirculation and scavenge reactive nitrogen species, thus protecting the tubular epithelium even when administered after the onset of sepsis.

TL;DR: The first time-dependent studies to document changes in renal hemodynamic changes occur early after sepsis demonstrate that targeting the later oxidant generation can break the cycle of injury and enable the microcirculation and renal function to recover.