Kathryn Owens

TL;DR: This work studied the cell-cell interactome of fetal placental trophoblast cells and maternal endometrial stromal cells, using single-cell transcriptomics and finds a highly cell-type-specific expression of G-protein-coupled receptors, implying that ligand-receptor profiles could be a reliable tool for cell type identification.

TL;DR: Placentas from pregnancies complicated by fetal HLHS are characterized by abnormal parenchymal morphology, suggesting immature structure may be due to vascular abnormalities, and increased leptin expression may indicate an attempt to compensate for these vascular abnormalities.

TL;DR: It is demonstrated that fetal wastage triggered by prenatal Listeria monocytogenes infection is driven by placental recruitment of CXCL9-producing inflammatory neutrophils and macrophages that promote infiltration of fetal-specific T cells into the decidua and suggested that therapeutically reinforcing this pathway represents a universal approach for mitigating immune-mediated pregnancy complications.

TL;DR: A nanostructure delivery system complexed with the IGF-1 gene to treat the placenta representing innovative building blocks towards human placental gene therapies is employed.

TL;DR: The current study confirms that the nanoparticle is capable of uptake in human placental syncytium which results in enhanced transgene expression, functional changes to cellular activity and protection against increased oxidative stress.