Jamie Maziarz

TL;DR: It is found that variants at the EBF1, EEFSEC, AGTR2, WNT4, ADCY5, and RAP2C loci were associated with gestational duration and variants atThe EBF 1, EE FSEC, and AG TR2 loci with preterm birth.

TL;DR: This work studied the cell-cell interactome of fetal placental trophoblast cells and maternal endometrial stromal cells, using single-cell transcriptomics and finds a highly cell-type-specific expression of G-protein-coupled receptors, implying that ligand-receptor profiles could be a reliable tool for cell type identification.

TL;DR: The data suggest that implantation in eutherians is derived from an ancestral inflammatory reaction to embryo attachment in the therian ancestor, and the ability to shift from an inflammatory attachment reaction to a noninflammatory period of pregnancy was a key innovation in e Lutherian mammals that allowed an extended period of intimate placentation.

TL;DR: A genomewide association study in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (<37 weeks) birth as a dichotomous outcome is performed.

TL;DR: It is shown that a novel cell type of eutherians mammals, the decidual stromal cell (DSC), evolved by rewiring an ancestral cellular stress response, and proposed that rewired of cellular stress responses was an important mechanism for the evolution of the eutherian decidUAL cell type.