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Noura H. Abd Ellah
Researcher at Assiut University
Publications - 25
Citations - 515
Noura H. Abd Ellah is an academic researcher from Assiut University. The author has contributed to research in topics: Drug delivery & Biofilm. The author has an hindex of 9, co-authored 22 publications receiving 258 citations. Previous affiliations of Noura H. Abd Ellah include University of Cincinnati.
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Journal ArticleDOI
Surface functionalization of polymeric nanoparticles for tumor drug delivery: approaches and challenges
TL;DR: This work summarizes methods used through the literature for surface modification of polymeric NPs, then discusses challenges that face researchers either in decorating NPs with desired surface functionalities, characterizing functionalized surfaces or achieving intended cellular interactions and in vivo effects.
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Nanomedicine as a promising approach for diagnosis, treatment and prophylaxis against COVID-19.
Noura H. Abd Ellah,Sheryhan F Gad,Sheryhan F Gad,Khalid Muhammad,Gaber El-Saber Batiha,Gaber El-Saber Batiha,Helal F Hetta,Helal F Hetta +7 more
TL;DR: Interestingly, nanomedicine as a promising therapeutic approach could effectively help win the battle between coronaviruses (CoVs) and host cells, in the fields of vaccination, diagnosis and therapy.
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Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii.
Helal F Hetta,Helal F Hetta,Israa M.S. Al-Kadmy,Israa M.S. Al-Kadmy,Saba Saadoon Khazaal,Suhad Abbas,Ahmed Suhail,Mohamed A El-Mokhtar,Noura H. Abd Ellah,Esraa A. Ahmed,Esraa A. Ahmed,Rasha B. Abd-ellatief,Eman A. El-Masry,Gaber El-Saber Batiha,Azza Elkady,Nahed A. Mohamed,Abdelazeem M. Algammal +16 more
Abstract: We aimed to isolate Acinetobacter baumannii (A. baumannii) from wound infections, determine their resistance and virulence profile, and assess the impact of Silver nanoparticles (AgNPs) on the bacterial growth, virulence and biofilm-related gene expression. AgNPs were synthesized and characterized using TEM, XRD and FTIR spectroscopy. A. baumannii (n = 200) were isolated and identified. Resistance pattern was determined and virulence genes (afa/draBC, cnf1, cnf2, csgA, cvaC, fimH, fyuA, ibeA, iutA, kpsMT II, PAI, papC, PapG II, III, sfa/focDE and traT) were screened using PCR. Biofilm formation was evaluated using Microtiter plate method. Then, the antimicrobial activity of AgNPs was evaluated by the well-diffusion method, growth kinetics and MIC determination. Inhibition of biofilm formation and the ability to disperse biofilms in exposure to AgNPs were evaluated. The effect of AgNPs on the expression of virulence and biofilm-related genes (bap, OmpA, abaI, csuA/B, A1S_2091, A1S_1510, A1S_0690, A1S_0114) were estimated using QRT-PCR. In vitro infection model for analyzing the antibacterial activity of AgNPs was done using a co-culture infection model of A. baumannii with human fibroblast skin cell line HFF-1 or Vero cell lines. A. baumannii had high level of resistance to antibiotics. Most of the isolates harbored the fimH, afa/draBC, cnf1, csgA and cnf2, and the majority of A. baumannii produced strong biofilms. AgNPs inhibited the growth of A. baumannii efficiently with MIC ranging from 4 to 25 µg/ml. A. baumannii showed a reduced growth rate in the presence of AgNPs. The inhibitory activity and the anti-biofilm activity of AgNPs were more pronounced against the weak biofilm producers. Moreover, AgNPs decreased the expression of kpsMII , afa/draBC,bap, OmpA, and csuA/B genes. The in vitro infection model revealed a significant antibacterial activity of AgNPs against extracellular and intracellular A. baumannii. AgNPs highly interrupted bacterial multiplication and biofilm formation. AgNPs downregulated the transcription level of important virulence and biofilm-related genes. Our findings provide an additional step towards understanding the mechanisms by which sliver nanoparticles interfere with the microbial spread and persistence.
Journal ArticleDOI
Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy.
Noura H. Abd Ellah,Leeanne Taylor,Weston Troja,Kathryn Owens,Neil Ayres,Giovanni M. Pauletti,Helen Jones +6 more
TL;DR: A nanostructure delivery system complexed with the IGF-1 gene to treat the placenta representing innovative building blocks towards human placental gene therapies is employed.
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Pleurotus sajor-caju-Mediated Synthesis of Silver and Gold Nanoparticles Active against Colon Cancer Cell Lines: A New Era of Herbonanoceutics.
Vivek K. Chaturvedi,Navneet Yadav,Neeraj Kumar Rai,Noura H. Abd Ellah,Raghvendra A. Bohara,Ibrahim F. Rehan,Najat Marraiki,Gaber El-Saber Batiha,Helal F Hetta,Helal F Hetta,M. P. Singh +10 more
TL;DR: The results suggest that the newly adopted synthesis method may ensure the dual benefits from phyto ingredients which further enhances the effectiveness of advanced nanomedicine.