K
Kathryn Welch
Researcher at Parke-Davis
Publications - 8
Citations - 552
Kathryn Welch is an academic researcher from Parke-Davis. The author has contributed to research in topics: In vivo & Cholesterol. The author has an hindex of 7, co-authored 8 publications receiving 537 citations.
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Journal ArticleDOI
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties
Sandra M. Sendobry,Joseph A. Cornicelli,Kathryn Welch,Thomas M.A. Bocan,Bradley Dean Tait,Bharat K. Trivedi,Norman L. Colbry,Richard D. Dyer,Steven J. Feinmark,Alan Daugherty +9 more
TL;DR: Results are consistent with a role for 15‐LO in atherogenesis and plasma concentrations achieved in vivo did not inhibit low‐density lipoprotein (LDL) oxidation in vitro.
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A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit
Thomas M.A. Bocan,Wendy S. Rosebury,Sandra Bak Mueller,Susan L. Kuchera,Kathryn Welch,Alan Daugherty,Joseph A. Cornicelli +6 more
TL;DR: PD146176 can limit monocyte macrophage enrichment of atherosclerotic lesions and can attenuate development of fibrofoamy and fibrous plaque lesions in the absence of changes in plasma total or lipoprotein cholesterol concentrations.
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Interleukin-4 augments acetylated LDL-induced cholesterol esterification in macrophages
TL;DR: Two cytokines that have been demonstrated previously to down-regulate SR-A, TNF-alpha and TGF-beta, antagonized the IL-4-induced augmentation of cholesterol esterification in the context of atherosclerotic lesions.
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Scavenger Receptors are Present on Rabbit Aortic Endothelial Cells In Vivo
TL;DR: The presence of scavenger receptors in rabbit endothelium in vivo is demonstrated, which may have fundamental implications for lipoprotein metabolism by the arterial wall.
Journal Article
Absence of T Lymphocyte-Derived Cytokines Fails to Diminish Macrophage 12/15-Lipoxygenase Expression In Vivo
TL;DR: Neither IL-4 nor IL-13 secretion is a requirement for macrophage 15- LO expression in vivo, and the activation of 12/15-LO expression appears to be related to prolonged residence within the peritoneum.