K
Kathy L. Moser
Researcher at University of Minnesota
Publications - 6
Citations - 801
Kathy L. Moser is an academic researcher from University of Minnesota. The author has contributed to research in topics: Gene & k-nearest neighbors algorithm. The author has an hindex of 6, co-authored 6 publications receiving 770 citations.
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Journal ArticleDOI
Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes
Lindsey A. Criswell,Kirsten A. Pfeiffer,Raymond F. Lum,Bonnie Gonzales,Jill Novitzke,Marlena Kern,Kathy L. Moser,Ann B. Begovich,Victoria E.H. Carlton,Wentian Li,Annette Lee,Ward A. Ortmann,Timothy W. Behrens,Peter K. Gregersen +13 more
TL;DR: A recently described functional single-nucleotide polymorphism in the intracellular tyrosine phosphatase (PTPN22) confers risk of four separate autoimmune phenotypes in these families: T1D, RA, SLE, and Hashimoto thyroiditis; these findings suggest a common underlying etiologic pathway for some, but not all, autoimmune disorders.
Journal ArticleDOI
A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset
Li Li,Wei Jiang,Xia Li,Xia Li,Xia Li,Kathy L. Moser,Zheng Guo,Zheng Guo,Zheng Guo,Lei Du,Qiuju Wang,Eric J. Topol,Qing Kenneth Wang,Shaoqi Rao,Shaoqi Rao,Shaoqi Rao +15 more
TL;DR: A robust gene selection approach based on a hybrid between genetic algorithm and support vector machine is formalized and the resulting classifier (the optimal gene subset) has achieved the highest accuracy (99%) for prediction of independent microarray samples in comparisons with marginal filters.
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Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12.
Patrick M. Gaffney,Carl D. Langefeld,Robert R. Graham,Ward A. Ortmann,Adrienne H. Williams,Peter R. Rodine,Kathy L. Moser,Timothy W. Behrens +7 more
TL;DR: The presence of systemic lupus erythematosus (SLE) susceptibility genes on chromosome 20 is suggested by the observation of genetic linkage in several independent SLE family collections and the possibility of epistatic relationships among loci within the 20q12, 20q13, and 16q12 regions in SLE families is suggested.
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Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.
R. Nolsoe,Jennifer A. Kelly,Flemming Pociot,Kathy L. Moser,O. P. Kristiansen,Thomas Mandrup-Poulsen,Thomas Mandrup-Poulsen,John B. Harley +7 more
TL;DR: It is concluded that the FAS/FASL promoter haplotypes are functional and that polymorphisms in FAS may contribute to thrombocytopenia in SLE.
Journal ArticleDOI
An ensemble method for gene discovery based on DNA microarray data.
TL;DR: This paper presents a novel ensemble method for gene extraction that can be tailored to fulfill multiple biological tasks including precise classification of biological types; disease gene mining; and target-driven gene networking.