A
Adrienne H. Williams
Researcher at Wake Forest University
Publications - 47
Citations - 5047
Adrienne H. Williams is an academic researcher from Wake Forest University. The author has contributed to research in topics: Single-nucleotide polymorphism & Lupus erythematosus. The author has an hindex of 31, co-authored 47 publications receiving 4693 citations. Previous affiliations of Adrienne H. Williams include Wake Forest Baptist Medical Center.
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Journal ArticleDOI
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
John B. Harley,John B. Harley,John B. Harley,Marta E. Alarcón-Riquelme,Lindsey A. Criswell,Chaim O. Jacob,Robert P. Kimberly,Kathy L. Moser,Kathy L. Moser,Betty P. Tsao,Timothy J. Vyse,Carl D. Langefeld,Swapan K. Nath,Joel M. Guthridge,Beth L. Cobb,Daniel B. Mirel,Miranda C. Marion,Adrienne H. Williams,Jasmin Divers,Wei Wang,Summer G. Frank,Bahram Namjou,Stacey Gabriel,Annette Lee,Peter K. Gregersen,Timothy W. Behrens,Timothy W. Behrens,Kimberly E. Taylor,Michelle M. A. Fernando,Raphael Zidovetzki,Patrick M. Gaffney,Patrick M. Gaffney,Jeffrey C. Edberg,John D. Rioux,Joshua O. Ojwang,Judith A. James,Joan T. Merrill,Gary S. Gilkeson,Michael F. Seldin,Hong Yin,Emily C. Baechler,Quan Zhen Li,Edward K. Wakeland,Gail R. Bruner,Kenneth M. Kaufman,Kenneth M. Kaufman,Jennifer A. Kelly +46 more
TL;DR: The results show that numerous genes, some with known immune-related functions, predispose to SLE, and evidence of association with replication is found at FCGR2A, PTPN22 and STAT4, regions previously associated with SLE and other autoimmune diseases.
Journal ArticleDOI
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Chieko Kyogoku,Carl D. Langefeld,Ward A. Ortmann,Annette Lee,Scott A. Selby,Victoria E.H. Carlton,Monica Chang,Paula S. Ramos,Emily C. Baechler,Franak Batliwalla,Jill Novitzke,Adrienne H. Williams,Clarence Gillett,Peter R. Rodine,Robert R. Graham,Kristin G. Ardlie,Patrick M. Gaffney,Kathy L. Moser,Michelle Petri,Ann B. Begovich,Peter K. Gregersen,Timothy W. Behrens +21 more
TL;DR: Genotyped 525 independent North American white individuals with systemic lupus erythematosus and compared the results with data generated from 1,961 white control individuals provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity.
Journal ArticleDOI
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.
Barry I. Freedman,Carl D. Langefeld,Kelly K. Andringa,Jennifer A. Croker,Adrienne H. Williams,Neva E. Garner,Daniel J. Birmingham,Lee A. Hebert,Pamela J. Hicks,Mark S. Segal,Jeffrey C. Edberg,Elizabeth E. Brown,Graciela S. Alarcón,Karen H. Costenbader,Mary E. Comeau,Lindsey A. Criswell,John B. Harley,Judith A. James,Diane L. Kamen,S. Sam Lim,Joan T. Merrill,Kathy L. Sivils,Timothy B. Niewold,Neha M. Patel,Michelle Petri,Rosalind Ramsey-Goldman,John D. Reveille,Jane E. Salmon,Betty P. Tsao,Keisha L. Gibson,Joyce R. Byers,Anna K. Vinnikova,Janice P. Lea,Bruce A. Julian,Robert P. Kimberly +34 more
TL;DR: The hypothesis that the apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in African Americans and rare in European Americans, contribute to the ethnic disparity in risk of lupus nephritis is investigated.
Journal ArticleDOI
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility
Jian Zhao,Hui Wu,Melanie Khosravi,Huijuan Cui,Xiaoxia Qian,Jennifer A. Kelly,Kenneth M. Kaufman,Kenneth M. Kaufman,Carl D. Langefeld,Adrienne H. Williams,Mary E. Comeau,Julie T. Ziegler,Miranda C. Marion,Adam Adler,Stuart B. Glenn,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Bernardo A. Pons-Estel,John B. Harley,John B. Harley,Sang Cheol Bae,So Young Bang,Soo-Kyung Cho,Chaim O. Jacob,Timothy J. Vyse,Timothy B. Niewold,Patrick M. Gaffney,Kathy L. Moser,Robert P. Kimberly,Jeffrey C. Edberg,Elizabeth E. Brown,Graciela S. Alarcón,Michelle Petri,Rosalind Ramsey-Goldman,Luis M. Vilá,John D. Reveille,Judith A. James,Judith A. James,Gary S. Gilkeson,Diane L. Kamen,Barry I. Freedman,Juan-Manuel Anaya,Joan T. Merrill,Lindsey A. Criswell,R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Anne M. Stevens,Anne M. Stevens,Joel M. Guthridge,Deh Ming Chang,Yeong Wook Song,Ji Ah Park,Eun Young Lee,Susan A. Boackle,Jennifer M. Grossman,Bevra H. Hahn,Timothy H.J. Goodship,Rita M. Cantor,Chack-Yung Yu,Nan Shen,Betty P. Tsao +61 more
TL;DR: Assessment of SNPs covering the CFH-CFHRs region suggested that the CFHR3-1Δ deletion within the SLE-associated block, but not the previously described exonic SNPs of CFH, might contribute to the development of SLE in EA, AA, and AS, providing new insights into the role of complement regulators.
Journal ArticleDOI
A genome scan for diabetic nephropathy in African Americans.
Donald W. Bowden,Carla J. Colicigno,Carl D. Langefeld,Michèle M. Sale,Adrienne H. Williams,Pamela J. Anderson,Stephen S. Rich,Barry I. Freedman +7 more
TL;DR: This first genome scan of diabetic nephropathy in African Americans reveals evidence for susceptibility loci on chromosomes 3q, 7p, and 18q, which may represent a type 2 diabetes susceptibility locus.