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Ward A. Ortmann
Researcher at University of Minnesota
Publications - 28
Citations - 6693
Ward A. Ortmann is an academic researcher from University of Minnesota. The author has contributed to research in topics: Lupus erythematosus & Haplotype. The author has an hindex of 19, co-authored 26 publications receiving 6275 citations. Previous affiliations of Ward A. Ortmann include Genentech.
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Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Chieko Kyogoku,Carl D. Langefeld,Ward A. Ortmann,Annette Lee,Scott A. Selby,Victoria E.H. Carlton,Monica Chang,Paula S. Ramos,Emily C. Baechler,Franak Batliwalla,Jill Novitzke,Adrienne H. Williams,Clarence Gillett,Peter R. Rodine,Robert R. Graham,Kristin G. Ardlie,Patrick M. Gaffney,Kathy L. Moser,Michelle Petri,Ann B. Begovich,Peter K. Gregersen,Timothy W. Behrens +21 more
TL;DR: Genotyped 525 independent North American white individuals with systemic lupus erythematosus and compared the results with data generated from 1,961 white control individuals provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity.
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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
Robert R. Graham,Robert R. Graham,Sergey V. Kozyrev,Emily C. Baechler,M.V. Prasad Linga Reddy,Robert M. Plenge,Robert M. Plenge,Jason W. Bauer,Ward A. Ortmann,Thearith Koeuth,Ma Francisca González Escribano,Bernardo A. Pons-Estel,Michelle Petri,Mark J. Daly,Mark J. Daly,Peter K. Gregersen,Javier Martin,David Altshuler,David Altshuler,Timothy W. Behrens,Marta E. Alarcón-Riquelme +20 more
TL;DR: A commonIRF5 haplotype driving elevated expression of multiple unique isoforms of IRF5 is an important genetic risk factor for SLE, establishing a causal role for type I IFN pathway genes in human autoimmunity.
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Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes
Lindsey A. Criswell,Kirsten A. Pfeiffer,Raymond F. Lum,Bonnie Gonzales,Jill Novitzke,Marlena Kern,Kathy L. Moser,Ann B. Begovich,Victoria E.H. Carlton,Wentian Li,Annette Lee,Ward A. Ortmann,Timothy W. Behrens,Peter K. Gregersen +13 more
TL;DR: A recently described functional single-nucleotide polymorphism in the intracellular tyrosine phosphatase (PTPN22) confers risk of four separate autoimmune phenotypes in these families: T1D, RA, SLE, and Hashimoto thyroiditis; these findings suggest a common underlying etiologic pathway for some, but not all, autoimmune disorders.
Journal ArticleDOI
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Robert R. Graham,Chieko Kyogoku,Snaevar Sigurdsson,Irina A. Vlasova,Leela Davies,Leela Davies,Emily C. Baechler,Robert M. Plenge,Robert M. Plenge,Thearith Koeuth,Ward A. Ortmann,Ward A. Ortmann,Geoffrey Hom,Geoffrey Hom,Jason W. Bauer,Clarence Gillett,Noël P. Burtt,Noël P. Burtt,Deborah S. Cunninghame Graham,Robert C. Onofrio,Robert C. Onofrio,Michelle Petri,Iva Gunnarsson,Elisabet Svenungsson,Lars Rönnblom,Gunnel Nordmark,Peter K. Gregersen,Kathy L. Moser,Patrick M. Gaffney,Lindsey A. Criswell,Timothy J. Vyse,Ann-Christine Syvänen,Paul R. Bohjanen,Mark J. Daly,Mark J. Daly,Timothy W. Behrens,Timothy W. Behrens,David Altshuler,David Altshuler +38 more
TL;DR: Evidence is found for three functional alleles of IRF5: the previously described exon 1B splice site variant, a 30-bp in-frame insertion/deletion variant of exon 6 that alters a proline-, glutamic acid-, serine- and threonine-rich domain region, and a variant in a conserved polyA+ signal sequence that alters the length of the 3′ UTR and stability of IRf5 mRNAs.