K
Katrin Pfleghaar
Researcher at Northwestern University
Publications - 5
Citations - 1643
Katrin Pfleghaar is an academic researcher from Northwestern University. The author has contributed to research in topics: Lamin & Chromatin. The author has an hindex of 5, co-authored 5 publications receiving 1506 citations. Previous affiliations of Katrin Pfleghaar include Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
Thomas Dechat,Katrin Pfleghaar,Kaushik Sengupta,Takeshi Shimi,Dale K. Shumaker,Liliana Solimando,Robert D. Goldman +6 more
TL;DR: An up-to-date overview of the functions of nuclear lamins is provided, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair.
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The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription
Takeshi Shimi,Katrin Pfleghaar,Katrin Pfleghaar,Shin Ichiro Kojima,Chan-Gi Pack,Irina Solovei,Anne E. Goldman,Stephen A. Adam,Dale K. Shumaker,Masataka Kinjo,Thomas Cremer,Robert D. Goldman +11 more
TL;DR: It is proposed that different lamins are organized into separate, but interacting, microdomains and that LB1 is essential for their organization and the organization and regulation of chromatin are influenced by interconnections between these laminmicrodomains.
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A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
Pekka Taimen,Katrin Pfleghaar,Takeshi Shimi,Dorothee Möller,Kfir Ben-Harush,Michael R. Erdos,Stephen A. Adam,Harald Herrmann,Ohad Medalia,Francis S. Collins,Anne E. Goldman,Robert D. Goldman +11 more
TL;DR: The results show that this central rod domain mutation affects nuclear architecture in a fashion distinctly different from the changes found in the most common form of progeria caused by the expression of LAΔ50/progerin.
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Chromosomal regions associated with prostate cancer risk localize to lamin B‐deficient microdomains and exhibit reduced gene transcription
TL;DR: Results imply that lamins are involved in chromatin organization and Pol II transcription, and provide insights into the development and progression of CaP.
Journal ArticleDOI
Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.
Katrin Pfleghaar,Pekka Taimen,Veronika Butin-Israeli,Takeshi Shimi,Sabine Langer-Freitag,Yolanda Markaki,Anne E. Goldman,Manfred Wehnert,Robert D. Goldman +8 more
TL;DR: The results suggest that the p.S143F progeria mutation has a severe impact not only on the structure of the lamina but also on the organization of interphase chromatin domains and transcription, which are likely to contribute to gene expression changes reported in progeria and other types of laminopathies.