S
Stephen A. Adam
Researcher at Northwestern University
Publications - 87
Citations - 11943
Stephen A. Adam is an academic researcher from Northwestern University. The author has contributed to research in topics: Lamin & Nuclear lamina. The author has an hindex of 47, co-authored 81 publications receiving 10679 citations. Previous affiliations of Stephen A. Adam include Johns Hopkins University & Scripps Health.
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Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.
TL;DR: Results indicate that the permeabilized cell system reproduces authentic nuclear protein import, and will prove powerful for investigating the biochemical pathway of nuclear transport.
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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Dale K. Shumaker,Thomas Dechat,Alexander Kohlmaier,Alexander Kohlmaier,Stephen A. Adam,Matthew R. Bozovsky,Michael R. Erdos,Maria Eriksson,Anne E. Goldman,Satya Khuon,Francis S. Collins,Thomas Jenuwein,Robert D. Goldman +12 more
TL;DR: The epigenetic changes described most likely represent molecular mechanisms responsible for the rapid progression of premature aging in HGPS patients.
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Importin α: A multipurpose nuclear-transport receptor
TL;DR: Control mechanisms that importin α exerts over the assembly and disassembly of the ternary complex are discussed and how new groups of importinα genes arose during the evolution of metazoan animals to function in development and differentiation is described.
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Autophagy mediates degradation of nuclear lamina
Zhixun Dou,Caiyue Xu,Greg Donahue,Takeshi Shimi,Ji-An Pan,Jiajun Zhu,Andrejs Ivanov,Brian C. Capell,Adam M. Drake,Parisha P. Shah,Joseph M. Catanzaro,M. Daniel Ricketts,Trond Lamark,Stephen A. Adam,Ronen Marmorstein,Wei-Xing Zong,Terje Johansen,Robert D. Goldman,Peter D. Adams,Shelley L. Berger +19 more
TL;DR: The study suggests that this new function of autophagy acts as a guarding mechanism protecting cells from tumorigenesis, and prevents activated RAS-induced lamin B1 loss and attenuates oncogene-induced senescence in primary human cells.
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The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription
Takeshi Shimi,Katrin Pfleghaar,Katrin Pfleghaar,Shin Ichiro Kojima,Chan-Gi Pack,Irina Solovei,Anne E. Goldman,Stephen A. Adam,Dale K. Shumaker,Masataka Kinjo,Thomas Cremer,Robert D. Goldman +11 more
TL;DR: It is proposed that different lamins are organized into separate, but interacting, microdomains and that LB1 is essential for their organization and the organization and regulation of chromatin are influenced by interconnections between these laminmicrodomains.