K
Katsutoshi Nakayama
Researcher at Akita University
Publications - 125
Citations - 5853
Katsutoshi Nakayama is an academic researcher from Akita University. The author has contributed to research in topics: Lung cancer & Autophagy. The author has an hindex of 38, co-authored 121 publications receiving 4926 citations. Previous affiliations of Katsutoshi Nakayama include Tohoku University & Jikei University School of Medicine.
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Journal ArticleDOI
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema.
Norihiro Yamada,Mutsuo Yamaya,Shoji Okinaga,Katsutoshi Nakayama,Kiyohisa Sekizawa,Shigeki Shibahara,Hidetada Sasaki +6 more
TL;DR: The findings suggest that the large size of a (GT)n repeat in the HO-1 gene promoter may reduceHO-1 inducibility by reactive oxygen species in cigarette smoke, thereby resulting in the development of CPE.
Journal ArticleDOI
Anticoagulant Therapy for Idiopathic Pulmonary Fibrosis
Hiroshi Kubo,Katsutoshi Nakayama,Masaru Yanai,Tomoko Suzuki,Mutsuo Yamaya,Mika Watanabe,Hidetada Sasaki +6 more
TL;DR: In this article, the effect of anticoagulant therapy on the survival of patients with idiopathic pulmonary fibrosis (IPF) was evaluated in five hospitals located in the Miyagi prefecture in Japan, including a university hospital, a Red Cross hospital, two public general hospitals and a municipal hospital.
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Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.
Shunsuke Minagawa,Jun Araya,Takanori Numata,Satoko Nojiri,Hiromichi Hara,Yoko Yumino,Makoto Kawaishi,Makoto Odaka,Toshiaki Morikawa,Stephen L. Nishimura,Katsutoshi Nakayama,Kazuyoshi Kuwano +11 more
TL;DR: The findings suggest that accelerated epithelial senescence plays a role in IPF pathogenesis through perpetuating abnormal epithelial-mesenchymal interactions, which can be antagonized by SIRT6.
Journal ArticleDOI
Insufficient autophagy in idiopathic pulmonary fibrosis.
Jun Araya,Jun Kojima,Naoki Takasaka,Saburo Ito,Satoko Fujii,Hiromichi Hara,Haruhiko Yanagisawa,Kenji Kobayashi,Chikako Tsurushige,Makoto Kawaishi,Noriki Kamiya,Jun Hirano,Makoto Odaka,Toshiaki Morikawa,Stephen L. Nishimura,Yoshinori Kawabata,Hiroshi Hano,Katsutoshi Nakayama,Kazuyoshi Kuwano +18 more
TL;DR: It is found that autophagy inhibition is sufficient to induce acceleration of epithelial cell senescence and myofibroblast differentiation in lung fibroblasts and is a promising clue for understanding the pathogenesis of IPF.
Journal ArticleDOI
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.
Masahiro Yoshida,Shunsuke Minagawa,Jun Araya,Taro Sakamoto,Hiromichi Hara,Kazuya Tsubouchi,Yusuke Hosaka,Akihiro Ichikawa,Nayuta Saito,Tsukasa Kadota,Nahoko Sato,Yusuke Kurita,Kenji Kobayashi,Saburo Ito,Hirohumi Utsumi,Hiroshi Wakui,Takanori Numata,Yumi Kaneko,Shohei Mori,Hisatoshi Asano,Makoto Yamashita,Makoto Odaka,Toshiaki Morikawa,Katsutoshi Nakayama,Takeo Iwamoto,Hirotaka Imai,Kazuyoshi Kuwano +26 more
TL;DR: In vivo and in vitro models show labile iron accumulation and enhanced lipid peroxidation with concomitant non-apoptotic cell death during cigarette smoke (CS) exposure, which are negatively regulated by GPx4 activity.