K
Katy J. Brocklehurst
Researcher at AstraZeneca
Publications - 11
Citations - 467
Katy J. Brocklehurst is an academic researcher from AstraZeneca. The author has contributed to research in topics: Glucokinase & Receptor. The author has an hindex of 10, co-authored 11 publications receiving 440 citations.
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Journal ArticleDOI
Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators
Katy J. Brocklehurst,Victoria A. Payne,Rick Davies,Debra Carroll,Helen L. Vertigan,Heather J. Wightman,Susan Aiston,Ian D. Waddell,Brendan Leighton,Matthew P. Coghlan,Loranne Agius +10 more
TL;DR: GK activators are potential antihyperglycemic agents for the treatment of type 2 diabetes through the stimulation of hepatic glucose metabolism by a mechanism independent of GKRP.
Journal ArticleDOI
GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans
Virginia M. Stone,Virginia M. Stone,Shalinee Dhayal,Katy J. Brocklehurst,Carol Lenaghan,Maria Sörhede Winzell,Mårten Hammar,Xiufeng Xu,David M. Smith,Noel G. Morgan +9 more
TL;DR: A Gpr120-knockout/β-galactosidase (LacZ) knock-in (KO/KI) mouse is constructed to examine the distribution and functional role of GPR120 in the endocrine pancreas and implies that GPR 120 is selectively present within the delta cells of murine islets and that it regulates somatostatin secretion.
Journal ArticleDOI
Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
James S. Scott,Alan Martin Birch,Katy J. Brocklehurst,Anders Broo,Hayley S. Brown,Roger John Butlin,David S. Clarke,Öjvind Davidsson,Anne Ertan,Kristin Goldberg,Sam D. Groombridge,Julian A. Hudson,David Laber,Andrew G. Leach,Philip A. MacFaul,Darren Mckerrecher,Adrian Pickup,Paul Schofield,Per H. Svensson,Pernilla Sörme,Joanne Teague +20 more
TL;DR: In this article, small-molecule crystallography was utilized to understand the intermolecular interactions in the solid state and resulted in a switch from an aryl sulphone to a 3-cyanopyridyl motif.
Journal ArticleDOI
Differences in regulatory properties between human and rat glucokinase regulatory protein.
TL;DR: Human GKRP is a more potent inhibitor of glucokinase than rat GK RP in the absence of fructose 6-phosphate or sorbitol 6- phosphate, and has a higher affinity for these ligands.
Journal ArticleDOI
The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119
Virginia M. Stone,Shalinee Dhayal,David M. Smith,Carol Lenaghan,Katy J. Brocklehurst,Noel G. Morgan +5 more
TL;DR: Whether GPR119, which regulates insulin secretion and is seen as a potential therapeutic target in type 2 diabetes, is involved and whether OEA is cytoprotective in β‐cells is examined.