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Kayla D. Battista
Researcher at Anschutz Medical Campus
Publications - 10
Citations - 819
Kayla D. Battista is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Colitis & Primary sclerosing cholangitis. The author has an hindex of 7, co-authored 10 publications receiving 482 citations. Previous affiliations of Kayla D. Battista include University of Colorado Boulder & University of Colorado Denver.
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Journal ArticleDOI
Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.
Leon Zheng,Caleb J. Kelly,Kayla D. Battista,Rachel E. M. Schaefer,Jordi M. Lanis,Erica E. Alexeev,Ruth Wang,Joseph C. Onyiah,Douglas J. Kominsky,Sean P. Colgan +9 more
TL;DR: These findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA–dependent repression of claudin-2 and enhance IEC barrier formation through activated Stat3 and HDAC inhibition.
Journal ArticleDOI
Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
Erica E. Alexeev,Jordi M. Lanis,Daniel J. Kao,Eric L. Campbell,Caleb J. Kelly,Kayla D. Battista,Mark E. Gerich,Brittany D. Jenkins,Seth T. Walk,Douglas J. Kominsky,Sean P. Colgan +10 more
TL;DR: A novel role of indole metabolites in anti-inflammatory pathways mediated by epithelial IL-10 signaling is defined and possible avenues for utilizing indoles as novel therapeutics in mucosal disease are identified.
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Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia
Jordi M. Lanis,Erica E. Alexeev,Valerie F. Curtis,David Kitzenberg,Daniel J. Kao,Kayla D. Battista,Mark E. Gerich,Louise E. Glover,Douglas J. Kominsky,Sean P. Colgan +9 more
TL;DR: Evidence is provided on the importance of IL-10 signaling in intestinal epithelia and the role of AHR in the regulation ofIL-10R1 expression in the colon and how this regulation is regulated by tryptophan metabolism is regulated.
Journal ArticleDOI
Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function.
J. Scott Lee,Ruth Wang,Erica E. Alexeev,Jordi M. Lanis,Kayla D. Battista,Louise E. Glover,Sean P. Colgan +6 more
TL;DR: An HPLC-based profiling method is developed to track changes in energy flux and adenylate metabolites during barrier development and restoration and indicates that hypoxanthine modulates energy metabolism in intestinal epithelial cells and is critical for intestinal barrier function.
Journal ArticleDOI
Oral vitamin B12 supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice.
Caleb J. Kelly,Caleb J. Kelly,Erica E. Alexeev,Linda Farb,Thad W. Vickery,Leon Zheng,Campbell Eric L,Campbell Eric L,David Kitzenberg,Kayla D. Battista,Douglas J. Kominsky,Douglas J. Kominsky,Douglas J. Kominsky,Charles E. Robertson,Daniel N. Frank,Sally P. Stabler,Sean P. Colgan +16 more
TL;DR: Microbial diversity was unaffected by this intervention, however a selective decrease in Bacteroides was observed with B12 treatment, and no difference in markers of DSS-induced colitis were detected with B 12 treatment.