J
Jordi M. Lanis
Researcher at Anschutz Medical Campus
Publications - 21
Citations - 1905
Jordi M. Lanis is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Colitis & Inflammation. The author has an hindex of 8, co-authored 16 publications receiving 1224 citations. Previous affiliations of Jordi M. Lanis include University of Colorado Boulder & University of Colorado Denver.
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Journal ArticleDOI
Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function
Caleb J. Kelly,Leon Zheng,Eric L. Campbell,Bejan Saeedi,Carsten C. Scholz,Amanda Bayless,Kelly Wilson,Louise E. Glover,Douglas J. Kominsky,Aaron Magnuson,Tiffany L. Weir,Stefan F. Ehrentraut,Stefan F. Ehrentraut,Christina Pickel,Kristine A. Kuhn,Jordi M. Lanis,Vu Nguyen,Cormac T. Taylor,Sean P. Colgan +18 more
TL;DR: A mechanism where host-microbe interactions augment barrier function in the distal gut is highlighted, where the influences of butyrate are lost in cells lacking HIF, thus linkingbutyrate metabolism to stabilized HIF and barrier function.
Journal ArticleDOI
Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.
Leon Zheng,Caleb J. Kelly,Kayla D. Battista,Rachel E. M. Schaefer,Jordi M. Lanis,Erica E. Alexeev,Ruth Wang,Joseph C. Onyiah,Douglas J. Kominsky,Sean P. Colgan +9 more
TL;DR: These findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA–dependent repression of claudin-2 and enhance IEC barrier formation through activated Stat3 and HDAC inhibition.
Journal ArticleDOI
Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
Erica E. Alexeev,Jordi M. Lanis,Daniel J. Kao,Eric L. Campbell,Caleb J. Kelly,Kayla D. Battista,Mark E. Gerich,Brittany D. Jenkins,Seth T. Walk,Douglas J. Kominsky,Sean P. Colgan +10 more
TL;DR: A novel role of indole metabolites in anti-inflammatory pathways mediated by epithelial IL-10 signaling is defined and possible avenues for utilizing indoles as novel therapeutics in mucosal disease are identified.
Journal ArticleDOI
Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia
Jordi M. Lanis,Erica E. Alexeev,Valerie F. Curtis,David Kitzenberg,Daniel J. Kao,Kayla D. Battista,Mark E. Gerich,Louise E. Glover,Douglas J. Kominsky,Sean P. Colgan +9 more
TL;DR: Evidence is provided on the importance of IL-10 signaling in intestinal epithelia and the role of AHR in the regulation ofIL-10R1 expression in the colon and how this regulation is regulated by tryptophan metabolism is regulated.
Journal ArticleDOI
Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function.
J. Scott Lee,Ruth Wang,Erica E. Alexeev,Jordi M. Lanis,Kayla D. Battista,Louise E. Glover,Sean P. Colgan +6 more
TL;DR: An HPLC-based profiling method is developed to track changes in energy flux and adenylate metabolites during barrier development and restoration and indicates that hypoxanthine modulates energy metabolism in intestinal epithelial cells and is critical for intestinal barrier function.