K
Kazuhiko Yoshida
Researcher at Hokkaido University
Publications - 13
Citations - 1241
Kazuhiko Yoshida is an academic researcher from Hokkaido University. The author has contributed to research in topics: Cornea & Neurotrophic factors. The author has an hindex of 12, co-authored 13 publications receiving 1196 citations. Previous affiliations of Kazuhiko Yoshida include University of California, San Diego.
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Journal ArticleDOI
Microglia–Müller Glia Cell Interactions Control Neurotrophic Factor Production during Light-Induced Retinal Degeneration
Takayuki Harada,Chikako Harada,Shinichi Kohsaka,Etsuko Wada,Kazuhiko Yoshida,Shigeaki Ohno,Hiroshi Mamada,Kohichi Tanaka,Kohichi Tanaka,Luis F. Parada,Keiji Wada +10 more
TL;DR: It is demonstrated the possibility that functional glia–glia interactions constitute the key mechanism by which microglia-derived NGF, brain-derived neurotrophic factor (BDNF), and CNTF indirectly influence photoreceptor survival, although the receptors for these neurotrophic factors are absent from photoreceptors.
Journal ArticleDOI
IKKα controls formation of the epidermis independently of NF-κB
Yinling Hu,Véronique Baud,Takefumi Oga,Takefumi Oga,Keun Il Kim,Kazuhiko Yoshida,Kazuhiko Yoshida,Michael Karin +7 more
TL;DR: It is shown that the unique function of IKKα in control of keratinocyte differentiation is not exerted through its IκB kinase activity or through NF-κB, but instead, IKK α controls production of a soluble factor that induces keratinocytes differentiation.
Journal ArticleDOI
Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats.
TL;DR: The data reveal that NGF-producing grafts sustain a significantly higher proportion of NGF receptor-immunoreactive septal neurons following axotomy and promote axon regeneration and cholinergic reinnervation of dentate granular neurons by these lesioned neurons.
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Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration
C Harada,T Harada,H.-M.A Quah,Fumihiko Maekawa,Kazuhiko Yoshida,Shigeaki Ohno,Keiji Wada,Luis F. Parada,Kohichi Tanaka +8 more
TL;DR: Observations suggest that GDNF, NTN and their receptors are involved in the regulation of trophic factor production in retinal glial cells, and that functional glia-neuron network may utilize GDNF family for the protection of neural cells during retinal degeneration.
Journal Article
Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection.
Kazuhiko Yoshida,Kazuhiko Yoshida,Axcel Behrens,Helen Le-Niculescu,Erwin F. Wagner,Takayuki Harada,Junko Imaki,Shigeaki Ohno,Michael Karin +8 more
TL;DR: There is a partial but significant contribution of JNP to the induction of apoptosis in RGCs by ON transection, and Retrograde labeling showed that the number of the R GCs in the retinas on the injured side of the c-Jun(AA) mice was significantly higher than in wild-type mice 14 days after the lesion.