L
Luis F. Parada
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 226
Citations - 40239
Luis F. Parada is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Trk receptor & Neurofibromin 1. The author has an hindex of 93, co-authored 223 publications receiving 37931 citations. Previous affiliations of Luis F. Parada include National Institutes of Health & University of Texas System.
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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
TL;DR: The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
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A restricted cell population propagates glioblastoma growth after chemotherapy
Jian Chen,Yanjiao Li,Tzong-Shiue Yu,Tzong-Shiue Yu,Renée M. McKay,Dennis K. Burns,Steven G. Kernie,Luis F. Parada +7 more
TL;DR: A relatively quiescent subset of endogenous glioma cells, with properties similar to those proposed for cancer stem cells, is responsible for sustaining long-term tumour growth through the production of transient populations of highly proliferative cells.
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The trk proto-oncogene product: a signal transducing receptor for nerve growth factor
TL;DR: Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar.
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High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
TL;DR: Reconstitution experiments reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor and the tyrosine kinase trk gene product.
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Cellular Oncogenes and Multistep Carcinogenesis
TL;DR: Two dozen cellular proto-oncogenes have been discovered to date through the study of retroviruses and the use of gene transfer, and recent work provides experimental strategies by which many of them, as well as oncogene of DNA tumor viruses, may be placed into functional categories.