K
Kohichi Tanaka
Researcher at Tokyo Medical and Dental University
Publications - 188
Citations - 13145
Kohichi Tanaka is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Glutamate receptor & Glutamate aspartate transporter. The author has an hindex of 56, co-authored 173 publications receiving 12201 citations. Previous affiliations of Kohichi Tanaka include Kyoto University & Saga Group.
Papers
More filters
Journal ArticleDOI
Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Kohichi Tanaka,Kei Watase,Toshiya Manabe,Keiko Yamada,Masahiko Watanabe,Katsunobu Takahashi,Hisayuki Iwama,Toru Nishikawa,Nobutsune Ichihara,Tateki Kikuchi,Shigeru Okuyama,Naoya Kawashima,Seiji Hori,Misato Takimoto,Keiji Wada +14 more
TL;DR: Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury, which can be attributed to elevated levels of residual glutamate in the brains of these mice.
Journal ArticleDOI
Structure and functional expression of the cloned rat neurotensin receptor
TL;DR: The molecular nature of the neurotensin receptor is disclosed, which mediates the diverse neuronal and peripheral actions of neurotens in by effecting the G protein-associated second messenger system.
Journal ArticleDOI
Molecular characterization of a functional cDNA for rat substance P receptor.
Yasunori Yokota,Yoshiki Sasai,Kohichi Tanaka,Takeshi Fujiwara,Kunihiro Tsuchida,Ryuichi Shigemoto,Akira Kakizuka,Hiroaki Ohkubo,S Nakanishi +8 more
TL;DR: The observed sequence similarity and divergence would contribute to the expression of similar but pharmacologically distinguishable activities of the two tachykinin receptors.
Journal ArticleDOI
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice.
Kei Watase,Kouichi Hashimoto,Masanobu Kano,Keiko Yamada,Masahiko Watanabe,Yoshiro Inoue,Shigeru Okuyama,Takashi Sakagawa,Shin-ichi Ogawa,Naoya Kawashima,Seiji Hori,Misato Takimoto,Keiji Wada,Kohichi Tanaka +13 more
TL;DR: Results indicate that GLAST plays active roles both in the cerebellar climbing fibre synapse formation and in preventing excitotoxic Cerebellar damage after acute brain injury.
Journal ArticleDOI
Glutamate Transporter GLAST Is Expressed in the Radial Glia–Astrocyte Lineage of Developing Mouse Spinal Cord
Takashi Shibata,Keiko Yamada,Masahiko Watanabe,Kazuhiro Ikenaka,Keiji Wada,Kohichi Tanaka,Yoshiro Inoue +6 more
TL;DR: The distinct changes in the cell position and morphology suggest that both the migration and transformation of radial glia cells begin in the spinal cord between E13 and E15, when the active stage of neuronal migration is over.