T
Tadashi Kaname
Researcher at University of the Ryukyus
Publications - 100
Citations - 2995
Tadashi Kaname is an academic researcher from University of the Ryukyus. The author has contributed to research in topics: Exome sequencing & Gene. The author has an hindex of 22, co-authored 100 publications receiving 2557 citations. Previous affiliations of Tadashi Kaname include Imperial College London & National Institutes of Health.
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Journal ArticleDOI
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome
Tetsuya Niihori,Yoko Aoki,Yoko Narumi,Giovanni Neri,Hélène Cavé,Alain Verloes,Nobuhiko Okamoto,Raoul C.M. Hennekam,Gabriele Gillessen-Kaesbach,Dagmar Wieczorek,Maria Ines Kavamura,Kenji Kurosawa,Hirofumi Ohashi,Louise C. Wilson,Delphine Héron,Dominique Bonneau,Giuseppina Corona,Tadashi Kaname,Kenji Naritomi,Clarisse Baumann,Naomichi Matsumoto,Kumi Kato,Shigeo Kure,Yoichi Matsubara +23 more
TL;DR: Dysregulation of the RAS-RAF-ERK pathway is a common molecular basis for the three related disorders of Cardio-facio-cutaneous syndrome, which phenotypically overlaps with Noonan and Costello syndrome.
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Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.
Yoshinori Tsurusaki,Nobuhiko Okamoto,Hirofumi Ohashi,Tomoki Kosho,Yoko Imai,Yumiko Hibi-Ko,Tadashi Kaname,Kenji Naritomi,Hiroshi Kawame,Hiroshi Kawame,Keiko Wakui,Yoshimitsu Fukushima,Tomomi Homma,Mitsuhiro Kato,Yoko Hiraki,Takanori Yamagata,Shoji Yano,Seiji Mizuno,Satoru Sakazume,Takuma Ishii,Toshiro Nagai,Masaaki Shiina,Kazuhiro Ogata,Tohru Ohta,Norio Niikawa,Satoko Miyatake,Ippei Okada,Takeshi Mizuguchi,Hiroshi Doi,Hirotomo Saitsu,Noriko Miyake,Naomichi Matsumoto +31 more
TL;DR: By exome sequencing, de novo SMARCB1 mutations are found in two of five individuals with typical Coffin-Siris syndrome (CSS), a rare autosomal dominant anomaly syndrome.
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A SNP in the ABCC11 gene is the determinant of human earwax type
Koh-ichiro Yoshiura,Akira Kinoshita,Takafumi Ishida,Aya Ninokata,Toshihisa Ishikawa,Tadashi Kaname,Makoto Bannai,Katsushi Tokunaga,Shunro Sonoda,Ryoichi Komaki,Makoto Ihara,Vladimir Saenko,Gabit Alipov,Ichiro Sekine,Kazuki Komatsu,Haruo Takahashi,Mitsuko Nakashima,Nadiya Sosonkina,Christophe K. Mapendano,Mohsen Ghadami,Masayo Nomura,Desheng Liang,Nobutomo Miwa,Dae Kwang Kim,Ariuntuul Garidkhuu,Nagato Natsume,Tohru Ohta,Hiroaki Tomita,Akira Kaneko,Mihoko Kikuchi,Graciela Russomando,Kenji Hirayama,Minaka Ishibashi,Aya Takahashi,Naruya Saitou,Jeffery C. Murray,Susumu Saito,Yusuke Nakamura,Norio Niikawa +38 more
TL;DR: It is shown that a SNP, 538G → A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type, and this is the first example of DNA polymorphism determining a visible genetic trait.
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Neointima formation in a restenosis model is suppressed in midkine-deficient mice.
Mitsuru Horiba,Kenji Kadomatsu,Eishin Nakamura,Hisako Muramatsu,Shinya Ikematsu,Sadatoshi Sakuma,Kenji Hayashi,Yukio Yuzawa,Seiichi Matsuo,Masafumi Kuzuya,Tadashi Kaname,Makoto Hirai,Hidehiko Saito,Takashi Muramatsu +13 more
TL;DR: Results indicate that MK plays a critical role in neointima formation at least in part owing to its ability to mediate leukocyte recruitment and solvent MK bound to the substratum induced migration of macrophages in vitro.
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Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome
Mark C. Hannibal,Kati J. Buckingham,Sarah B. Ng,Jeffrey E. Ming,Anita E. Beck,Anita E. Beck,Margaret J. Mcmillin,Heidi I. S. Gildersleeve,Abigail W. Bigham,Holly K. Tabor,Holly K. Tabor,Heather C Mefford,Heather C Mefford,Joseph Cook,Koh-ichiro Yoshiura,Tadashi Matsumoto,Naomichi Matsumoto,Noriko Miyake,Hidefumi Tonoki,Kenji Naritomi,Tadashi Kaname,Toshiro Nagai,Hirofumi Ohashi,Kenji Kurosawa,Jia Woei Hou,Tohru Ohta,Deshung Liang,Akira Sudo,Colleen A. Morris,Siddharth Banka,Graeme C.M. Black,Jill Clayton-Smith,Deborah A. Nickerson,Elaine H. Zackai,Tamim H. Shaikh,Dian Donnai,Norio Niikawa,Jay Shendure,Michael J. Bamshad,Michael J. Bamshad +39 more
TL;DR: In this paper, the authors reported on the screening of 110 families with Kabuki syndrome and found 81/110 (74%) mutations in the Trithorax-group histone methyltransferase, a protein important in the epigenetic control of active chromatin states.